[HTML][HTML] New epidermal-growth-factor-related insights into the pathogenesis of multiple sclerosis: is it also epistemology?

G Scalabrino - Frontiers in neurology, 2021 - frontiersin.org
Recent findings showing that epidermal growth factor (EGF) is significantly decreased in the
cerebrospinal fluid (CSF) and spinal cord (SC) of living or deceased multiple sclerosis (MS) …

[HTML][HTML] Epidermal growth factor in the CNS: A beguiling journey from integrated cell biology to multiple sclerosis. an extensive translational overview

G Scalabrino - Cellular and Molecular Neurobiology, 2022 - Springer
This article reviews the wealth of papers dealing with the different effects of epidermal
growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs) …

Growth factors and myelin regeneration in multiple sclerosis

HF Webster - Multiple Sclerosis Journal, 1997 - journals.sagepub.com
Insulin-like growth factor-I (IGF-I), platelet-derived growth factor (PDGF), fibroblast growth
factor (FGF) and ciliary neurotrophic factor (CNTF) are multifunctional growth factors which …

Immune system induction of nerve growth factor in an animal model of multiple sclerosis: implications in re-myelination and myelin RepairATION AND MYELIN …

C Acosta, C Cortes, K Altaweel… - CNS & Neurological …, 2015 - ingentaconnect.com
Nerve growth factor (NGF) expression is augmented during neuroinflammation. However, its
function in the dorsal root ganglia (DRG) and spinal cord (SC) during experimental …

Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis

TO Tobore - International journal of neuroscience, 2020 - Taylor & Francis
Background: Multiple sclerosis (MS) is a neurodegenerative disease caused by dysfunction
of the immune system that affects the central nervous system (CNS). It is characterized by …

High and dysregulated secretion of epidermal growth factor from immune cells of patients with relapsing-remitting multiple sclerosis

YA Levy, KM Fainberg, T Amidror, K Regev… - Journal of …, 2013 - Elsevier
We studied the secretion and regulation of epidermal growth factor (EGF) from immune cells
of patients with relapsing remitting multiple sclerosis (RR-MS), and the relevance of these …

[HTML][HTML] Neuroprotective effects of vascular endothelial growth factor A in the experimental autoimmune encephalomyelitis model of multiple sclerosis

W Lin - Neural Regeneration Research, 2017 - journals.lww.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS), characterized by multiple demyelinating plaques in the white matter. For decades …

[HTML][HTML] Newly identified deficiencies in the multiple sclerosis central nervous system and their impact on the remyelination failure

G Scalabrino - Biomedicines, 2022 - mdpi.com
The pathogenesis of multiple sclerosis (MS) remains enigmatic and controversial. Myelin
sheaths in the central nervous system (CNS) insulate axons and allow saltatory nerve …

The role of neurotrophic factors in the pathology and treatment of multiple sclerosis

D Mirowska-Guzel - Immunopharmacology and immunotoxicology, 2009 - Taylor & Francis
Multiple sclerosis (MS) is a chronic demyelinating disease of primary autoimmune origin
with essential component of subsequent axonal degeneration. It has been found that …

Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines …

P Villoslada, SL Hauser, I Bartke, J Unger… - The Journal of …, 2000 - rupress.org
Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which
an immune attack directed against myelin constituents causes myelin destruction and death …