Objective Back pain is associated with substantial Global Burden of Disease and is highly
comorbid with mood and anxiety symptoms and syndromes. However, mechanisms …

Background. Clinical and epidemiological studies have shown an association between
anxiety and depression and pain in the back and neck. The nature of this relationship is not …

There has recently been marked progress in identifying genetic risk factors for major
depression (MD) and bipolar disorder (BD); however, few systematic efforts have been …

Background People suffering from chronic pain are more likely to experience symptoms of
depression and anxiety. However, the mechanisms underlying this relationship remain …

Anxiety and depression commonly occur together resulting in worse health outcomes than
when they occur in isolation. We aimed to determine whether the genetic liability for …

Depression, anxiety, obesity and substance use are heritable and often co-occur. However,
the mechanisms underlying this co-occurrence are not fully understood. We estimated their …

Background Generalized anxiety and depression are extremely prevalent and debilitating.
There is evidence for age and sex variability in symptoms of depression, but despite …

Importance Depression and anxiety are common and highly comorbid, posing a clinical and
public health concern because such comorbidity is associated with poorer outcomes …

Background The close relationship between pain and mental health problems is well-
known, and psychological intervention can provide an effective alternative to medication …

Introduction: Chronic pain is a common condition with high socioeconomic and public health
burden. A wide range of psychiatric conditions are often comorbid with chronic pain and …