This article describes current oxygen-carrying solutions, four new products and new
indications to increase the benefit/risk ratio of haemoglobin-based oxygen carriers …

Three types of materials have been studied as candidate blood substitutes: the
perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin …

The development of oxygen (O 2)-carrying blood substitutes has evolved from the goal of
replicating blood O 2 transport properties to that of preserving microvascular and organ …

SEMISYNTHETIC or synthetic preparations of hemoglobin, now termed hemoglobin-based
oxygen carriers (HBOCs), have been in development as an alternative to erythrocytes for …

Blood transfusion is a remarkably safe, routine clinical procedure. However, the need for
sophisticated blood processing, storage and cross-matching, coupled with increasing …

The US blood supply is once again expanding (14 million units a year) and annual
estimated whole blood and red blood cell (RBC) transfusion now exceeds 12 million units …

The most common and widely transplanted tissue world wide is blood, which in 2000
resulted in the transfusion of 12.5 million units of blood in the US alone [Goodnough LT …

Under normal conditions, only 20–30% of the delivered oxygen is metabolised. In
normovolaemic anaemia, the organism reacts with increases in cardiac output and oxygen …

An alternative to blood transfusion, based on oxygen‐carrying solutions, has been sought
for over a century. The present 'first‐generation'haemoglobin‐products were based on …

Blood substitutes are products that are designed to replace whole blood (or) red blood cells
in the field of transfusion medicine. There are two major classes that belong to this new …