Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma
A sizeable fraction of multiple myeloma (MM) is expected to be explained by heritable
factors. Genome-wide association studies (GWAS) have successfully identified a number of …
factors. Genome-wide association studies (GWAS) have successfully identified a number of …
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
Background While genome-wide association studies (GWAS) of multiple myeloma (MM)
have identified variants at 23 regions influencing risk, the genes underlying these …
have identified variants at 23 regions influencing risk, the genes underlying these …
A polygenic risk score for multiple myeloma risk prediction
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a
solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk …
solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk …
Search for multiple myeloma risk factors using Mendelian randomization
The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-
wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian …
wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian …
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
JS Mitchell, N Li, N Weinhold, A Försti, M Ali… - Nature …, 2016 - nature.com
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis.
Genome-wide association studies have transformed our understanding of MM …
Genome-wide association studies have transformed our understanding of MM …
MyelomA genetics international consortium
G Morgan, HE Johnsen, H Goldschmidt… - Leukemia & …, 2012 - Taylor & Francis
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited
genetic susceptibility is provided by the two-fold increased risk of the disease seen in first …
genetic susceptibility is provided by the two-fold increased risk of the disease seen in first …
Identification of novel genetic loci for risk of multiple myeloma by functional annotation
A Macauda, K Briem, A Clay-Gilmour, W Cozen… - Leukemia, 2023 - nature.com
Multiple myeloma (MM) is one of the most common hematological malignancies, accounting
for 20% of all newly diagnosed hematological cancers [1]. The most recent data from Cancer …
for 20% of all newly diagnosed hematological cancers [1]. The most recent data from Cancer …
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
Genome-wide association studies (GWAS) have transformed our understanding of
susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained …
susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained …
Genetic predisposition for multiple myeloma
Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological
family studies going back to the 1920s have provided evidence for familial aggregation …
family studies going back to the 1920s have provided evidence for familial aggregation …
Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival
B Van Ness, C Ramos, M Haznadar, A Hoering… - BMC medicine, 2008 - Springer
Background We have engaged in an international program designated the Bank On A Cure,
which has established DNA banks from multiple cooperative and institutional clinical trials …
which has established DNA banks from multiple cooperative and institutional clinical trials …