Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma

JS Mitchell, DC Johnson, K Litchfield, P Broderick… - Scientific reports, 2015 - nature.com
A sizeable fraction of multiple myeloma (MM) is expected to be explained by heritable
factors. Genome-wide association studies (GWAS) have successfully identified a number of …

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

M Went, B Kinnersley, A Sud, DC Johnson… - Human genomics, 2019 - Springer
Background While genome-wide association studies (GWAS) of multiple myeloma (MM)
have identified variants at 23 regions influencing risk, the genes underlying these …

A polygenic risk score for multiple myeloma risk prediction

F Canzian, C Piredda, A Macauda… - European Journal of …, 2022 - nature.com
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a
solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk …

Search for multiple myeloma risk factors using Mendelian randomization

M Went, AJ Cornish, PJ Law, B Kinnersley… - Blood …, 2020 - ashpublications.org
The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-
wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian …

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

JS Mitchell, N Li, N Weinhold, A Försti, M Ali… - Nature …, 2016 - nature.com
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis.
Genome-wide association studies have transformed our understanding of MM …

MyelomA genetics international consortium

G Morgan, HE Johnsen, H Goldschmidt… - Leukemia & …, 2012 - Taylor & Francis
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited
genetic susceptibility is provided by the two-fold increased risk of the disease seen in first …

Identification of novel genetic loci for risk of multiple myeloma by functional annotation

A Macauda, K Briem, A Clay-Gilmour, W Cozen… - Leukemia, 2023 - nature.com
Multiple myeloma (MM) is one of the most common hematological malignancies, accounting
for 20% of all newly diagnosed hematological cancers [1]. The most recent data from Cancer …

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

M Went, A Sud, A Försti, BM Halvarsson… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have transformed our understanding of
susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained …

Genetic predisposition for multiple myeloma

M Pertesi, M Went, M Hansson, K Hemminki… - Leukemia, 2020 - nature.com
Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological
family studies going back to the 1920s have provided evidence for familial aggregation …

Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival

B Van Ness, C Ramos, M Haznadar, A Hoering… - BMC medicine, 2008 - Springer
Background We have engaged in an international program designated the Bank On A Cure,
which has established DNA banks from multiple cooperative and institutional clinical trials …