Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice
Carbon monoxide (CO) is a known endogenous signaling molecule with potential
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …
Activated charcoal dispersion of carbon monoxide prodrugs for oral delivery of CO in a pill
A novel orally bioavailable solid formulation to deliver a gaseous signaling molecule, carbon
monoxide (CO), was developed by adsorbing oxalyl saccharin, a newly developed organic …
monoxide (CO), was developed by adsorbing oxalyl saccharin, a newly developed organic …
Strategies toward Metal‐Free Carbon Monoxide Prodrugs: An Update
Q Min, X Ji - ChemMedChem, 2023 - Wiley Online Library
Carbon monoxide is an important gasotransmitter in mammals, with pleiotropic therapeutic
potential against a wide range of human diseases. However, clinical translation of CO is …
potential against a wide range of human diseases. However, clinical translation of CO is …
Toward carbon monoxide based therapeutics: carbon monoxide in a pill
As one of the three known gasotransmitters, carbon monoxide (CO) has demonstrated
therapeutic potential against a wide range of human diseases. However, development of CO …
therapeutic potential against a wide range of human diseases. However, development of CO …
Developing drug molecules for therapy with carbon monoxide
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
Toward carbon monoxide–based therapeutics: Critical drug delivery and developability issues
Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of
nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the …
nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the …
Organic CO prodrugs: Structure–CO‐release rate relationship studies
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …
“CO in a pill”: Towards oral delivery of carbon monoxide for therapeutic applications
Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …
Toward “CO in a Pill”: Silica-Immobilized Organic CO Prodrugs for Studying the Feasibility of Systemic Delivery of CO via In Situ Gastrointestinal CO Release
Carbon monoxide (CO), an endogenous signaling molecule, is known to exert a range of
pharmacological effects, including anti-inflammation, organ protection, and antimetastasis in …
pharmacological effects, including anti-inflammation, organ protection, and antimetastasis in …
A click-and-release approach to CO prodrugs
Carbon monoxide belongs to the family of signaling molecules and has been shown to
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …