Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice

M Wang, X Yang, Z Pan, Y Wang, LK De La Cruz… - Journal of Controlled …, 2020 - Elsevier
Carbon monoxide (CO) is a known endogenous signaling molecule with potential
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …

Activated charcoal dispersion of carbon monoxide prodrugs for oral delivery of CO in a pill

X Yang, W Lu, M Wang, LK De La Cruz, C Tan… - International journal of …, 2022 - Elsevier
A novel orally bioavailable solid formulation to deliver a gaseous signaling molecule, carbon
monoxide (CO), was developed by adsorbing oxalyl saccharin, a newly developed organic …

Strategies toward Metal‐Free Carbon Monoxide Prodrugs: An Update

Q Min, X Ji - ChemMedChem, 2023 - Wiley Online Library
Carbon monoxide is an important gasotransmitter in mammals, with pleiotropic therapeutic
potential against a wide range of human diseases. However, clinical translation of CO is …

Toward carbon monoxide based therapeutics: carbon monoxide in a pill

X Ji, B Wang - Pharmaceutical Patent Analyst, 2017 - Taylor & Francis
As one of the three known gasotransmitters, carbon monoxide (CO) has demonstrated
therapeutic potential against a wide range of human diseases. However, development of CO …

Developing drug molecules for therapy with carbon monoxide

CC Romao, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

Toward carbon monoxide–based therapeutics: Critical drug delivery and developability issues

X Ji, K Damera, Y Zheng, B Yu, LE Otterbein… - Journal of …, 2016 - Elsevier
Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of
nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the …

Organic CO prodrugs: Structure–CO‐release rate relationship studies

Z Pan, V Chittavong, W Li, J Zhang, K Ji… - … A European Journal, 2017 - Wiley Online Library
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …

“CO in a pill”: Towards oral delivery of carbon monoxide for therapeutic applications

X Yang, W Lu, M Wang, C Tan, B Wang - Journal of Controlled Release, 2021 - Elsevier
Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …

Toward “CO in a Pill”: Silica-Immobilized Organic CO Prodrugs for Studying the Feasibility of Systemic Delivery of CO via In Situ Gastrointestinal CO Release

X Yang, R Tripathi, M Wang, W Lu… - Molecular …, 2023 - ACS Publications
Carbon monoxide (CO), an endogenous signaling molecule, is known to exert a range of
pharmacological effects, including anti-inflammation, organ protection, and antimetastasis in …

A click-and-release approach to CO prodrugs

D Wang, E Viennois, K Ji, K Damera… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide belongs to the family of signaling molecules and has been shown to
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …