Osteoporosis and bone mass disorders: from gene pathways to treatments

F Rivadeneira, O Mäkitie - Trends in Endocrinology & Metabolism, 2016 - cell.com
Genomic technologies have evolved rapidly contributing to the understanding of diseases.
Genome-wide association studies (GWAS) and whole-exome sequencing have aided the …

A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

The genetics of bone mass and susceptibility to bone diseases

D Karasik, F Rivadeneira, ML Johnson - Nature Reviews Rheumatology, 2016 - nature.com
Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

Osteoporosis: a silent disease with complex genetic contribution

MM Golchin, L Heidari, SMH Ghaderian… - Journal of Genetics and …, 2016 - Elsevier
Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a
strong genetic component. In this review, the evidence for a genetic contribution to …

Genetics of osteoporosis

QY Huang, AWC Kung - Molecular Genetics and Metabolism, 2006 - Elsevier
Osteoporosis is a common disease with a strong genetic component. In recent years, some
progress has been made in understanding the genetic basis of osteoporosis. Genetic factors …

[图书][B] Fundamentals of osteoporosis

R Marcus, D Feldman, D Nelson, C Rosen - 2009 - books.google.com
Fundamentals of Osteoporosis offers a concise yet comprehensive source of all the latest
basic research related to osteoporosis in one reference work. Experts from all areas of …

[HTML][HTML] Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

L Zhang, HJ Choi, K Estrada, PJ Leo, J Li… - Human molecular …, 2014 - academic.oup.com
Aiming to identify novel genetic variants and to confirm previously identified genetic variants
associated with bone mineral density (BMD), we conducted a three-stage genome-wide …

Molecular genetic studies of gene identification for osteoporosis: the 2009 update

XH Xu, SS Dong, Y Guo, TL Yang, SF Lei… - Endocrine …, 2010 - academic.oup.com
Osteoporosis is a complex human disease that results in increased susceptibility to fragility
fractures. It can be phenotypically characterized using several traits, including bone mineral …

[HTML][HTML] An insight into the paradigms of osteoporosis: From genetics to biomechanics

F Al Anouti, Z Taha, S Shamim, K Khalaf, L Al Kaabi… - Bone reports, 2019 - Elsevier
Considered as one of the major epidemics of the 21st century, osteoporosis affects
approximately 200 million people globally, with significant worldwide impact on rates of …