Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …

Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics,
cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms …

Bone remodelling is an active and dynamic process that relies on the correct balance
between bone resorption by osteoclasts and bone deposition by osteoblasts. Moreover …

Osteoporosis is likely to become the most common disorder of our aging population. An
understanding of factors that affect the incidence of osteoporosis is critical if we are to …

Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

During the last 40 years, understanding of bone biology and the pathogenesis of
osteoporosis, the most common and impactful bone disease of old age, has improved …

Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …

Throughout life, bone is continuously remodelled to be able to fulfil its multiple functions. The
importance of strictly regulating the bone remodelling process, which is defined by the …

Osteoporosis is a major public health concern affecting millions of people worldwide and
resulting in significant economic costs. The condition is characterized by changes in bone …

In this review of the pathophysiology of osteoporosis, we summarize some of the key
mechanisms that may contribute to low bone mass and fragility and provide references to …