Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Clarification of the mechanisms underlying osteoclast differentiation enables us to
understand the physiology of bone metabolism as well as the pathophysiology of bone …

Context: A strong genetic influence on bone mineral density has been long established, and
modern genotyping technologies have generated a flurry of new discoveries about the …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …

Bone turnover, in which cells of the osteoclast lineage resorb bone and cells of the
osteoblast lineage deposit bone, normally occurs in a highly regulated manner throughout …

Bone mineral density (BMD) is a quantitative traits used as a surrogate phenotype for the
diagnosis of osteoporosis, a common metabolic disorder characterized by increased fracture …

Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

With an increase in the ageing population worldwide, the prevalence of osteoporosis
increases at an alarming rate in both male and female irrespective of their ethnicity. At …

Completely revised and updated, and utilizing the most current evidence and practice
guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the …