Epigenetic regulation of bone remodeling and its impacts in osteoporosis

C Ghayor, FE Weber - International journal of molecular sciences, 2016 - mdpi.com
Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

The role of epigenomics in osteoporosis and osteoporotic vertebral fracture

KT Kim, YS Lee, I Han - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …

Epigenetic mechanisms of bone regeneration and homeostasis

Y Liu, XL Zhang, L Chen, X Lin, D Xiong, F Xu… - Progress in Biophysics …, 2016 - Elsevier
Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of
several procedures, such as the osteogenic differentiation of mesenchymal stem cells as …

The roles of epigenetics regulation in bone metabolism and osteoporosis

F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Do epigenetic marks govern bone mass and homeostasis?

J Delgado-Calle, P Garmilla, JA Riancho - Current genomics, 2012 - ingentaconnect.com
Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

Epigenetic mechanisms in bone biology and osteoporosis: can they drive therapeutic choices?

F Marini, L Cianferotti, ML Brandi - International journal of molecular …, 2016 - mdpi.com
Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

New insights into the epigenetics of osteoporosis

JG Letarouilly, O Broux, A Clabaut - Genomics, 2019 - Elsevier
Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …

Epigenetic regulation of bone cells

KH Park-Min - Connective tissue research, 2017 - Taylor & Francis
Bone is a major organ in the skeletal system that supports and protects muscles and other
organs, facilitates movement and hematopoiesis, and forms a reservoir of minerals including …

Epigenetics and bone remodeling

A Husain, MA Jeffries - Current osteoporosis reports, 2017 - Springer
Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …

Molecular and genetic mechanisms of osteoporosis: implication for treatment

H Shen, RR Recker, HW Deng - Current molecular medicine, 2003 - ingentaconnect.com
Osteoporosis is a leading public health problem in our rapidly growing, aging population. It
is characterized by reduced bone mass and microarchitectural deterioration of bone tissue …