CasRx, a recently discovered member of the type VI CRISPR system with minimum size,
offers a new approach for RNA manipulation with high efficiency and specificity in …

Small extracellular vesicles (sEVs) are naturally occurring vesicles that have the potential to
be manipulated to become promising drug delivery vehicles for on-demand in vitro and in …

Genome editing of somatic cells via clustered regularly interspaced short palindromic
repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders …

The CRISPR-Cas9 system has quickly become the standard tool for genome editing. To
deliver this system to target cells, adeno-associated virus (AAV) vectors are commonly used …

Abstract CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave
single-strand RNAs, which is a promising treatment for various disorders by downregulation …

Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled …

Mutations in microRNA-96 (MIR96) cause autosomal dominant deafness-50 (DFNA50), a
form of delayed-onset hearing loss. Genome editing has shown efficacy in hearing recovery …

Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …

Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

CRISPR/Cas9 gene-editing technology shows great potential for treating a variety of
diseases, such as glioblastoma multiforme (GBM). However, CRISPR components suffer …