CasRx, a recently discovered member of the type VI CRISPR system with minimum size,
offers a new approach for RNA manipulation with high efficiency and specificity in …

Genome editing of somatic cells via clustered regularly interspaced short palindromic
repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders …

The CRISPR-Cas9 system has quickly become the standard tool for genome editing. To
deliver this system to target cells, adeno-associated virus (AAV) vectors are commonly used …

Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …

Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

Abstract CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave
single-strand RNAs, which is a promising treatment for various disorders by downregulation …

CRISPR/Cas9 gene-editing technology shows great potential for treating a variety of
diseases, such as glioblastoma multiforme (GBM). However, CRISPR components suffer …

Electroporation of the Cas9 ribonucleoprotein (RNP) complex offers the advantage of
preventing off-target cleavages and potential immune responses produced by long-term …

Tools for editing the genome and epigenome represent a new frontier in targeted
therapeutic intervention. Nonviral nanoparticle-based delivery systems are potentially the …

Arrayed genetic screens mediated by the CRISPR/Cas9 technology with single guide RNA
(sgRNA) libraries demand a high-throughput platform capable of transfecting diverse cell …