Amine-functionalized mesoporous silica nanoparticles (MSNPAs) are ideal carriers for
oligonucleotides for gene delivery and RNA interference. This investigation examines the …

Oligonucleotides used in gene therapy and silencing are fragile compounds that degrade
easily in biological environments. Porous biocompatible carrier particles may provide a …

Porous silica particles are potential transfection agents for nucleic acid-based therapies
because of their large specific surface areas and pore volumes and the ease with which they …

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and
antisense oligonucleotide (ASO), are powerful gene regulators, which have been …

The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …

A new general route for siRNA delivery is presented combining porous core–shell silica
nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the …

Silica nanoparticles with controlled diameter (∼ 70− 300 nm) and with uniform pores of 20
nm are prepared by a low temperature (10° C) synthetic method in the presence of a dual …

Novel mesoporous silica nanoparticles (LPMSNs) functionalised with degradable poly (2-
dimethylaminoethyl acrylate)(PDMAEA) have been developed (PDMAEA–LPMSNs) as …

A series of organically functionalized, MCM-41 type mesoporous silica nanoparticle
materials (PAP-LP-MSN and AP-PAP-MSN) with different pore sizes (5.7 nm and 2.5 nm …

Growing interest has been seen in non-pathogenic, safe, and effective gene therapy delivery
systems. There are many nucleic acid therapies that have been studied to alter the …