While insulin resistance (IR) is associated with inflammation in white adipose tissue, we
report a non-inflammatory adipose mechanism of high fat-induced IR mediated by loss of …

Pref-1/Dlk1 is made as an epidermal growth factor (EGF) repeat-containing transmembrane
protein but is cleaved by tumor necrosis factor alpha converting enzyme (TACE) to generate …

ABSTRACT Preadipocyte factor 1 (Pref-1) belongs to the Notch/Delta/Serrate family of
epidermal growth factor-like repeat-containing proteins. Pref-1 is highly expressed in 3T3-L1 …

OBJECTIVE—White adipose tissue is a critical regulator of whole-body glucose metabolism.
Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits adipocyte differentiation …

Pref-1 is a highly glycosylated Delta-like transmembrane protein containing six epidermal
growth factor-like repeats in the extracellular domain. Pref-1 is abundantly expressed in …

Macrophages are more abundant in adipose tissue from obese individuals than from those
of normal weight and may contribute to the metabolic consequences of obesity by producing …

Preadipocyte factor 1 (Pref-1) is found in preadipocytes but is absent in adipocytes. Pref-1 is
made as a transmembrane protein but is cleaved to generate a biologically active soluble …

In view of the central role of preadipocyte factor-1, adiponectin and leptin in white adipose
tissue function, the aim of the present study was to analyze the mRNA expression of these …

Obesity contributes significantly to the global health burden. A better understanding of
adipogenesis, the process of fat formation, may lead to the discovery of novel treatment …

Interferon regulatory factors (IRFs) play functionally diverse roles in the transcriptional
regulation of the immune system. We have previously shown that several IRFs are …