The ability to produce a concentrated urine is imposed by a uniquely low ambient oxygen
pressure in the renal medulla due to shunt diffusion within the vascular bundles. As the thick …

The introduction of new techniques for the determination of renal parenchymal oxygenation
and intrarenal microcirculation has elucidated some important aspects in the …

The kidney poses an interesting paradox with regard to the adequacy of its oxygen supply.
Its flow of blood is high in relation to its weight, and renal arteriovenous oxygen difference is …

We have previously developed a three-dimensional computational model of oxygen
transport in the renal medulla. In the present study, we used this model to quantify the …

Oxygen tension within the renal parenchyma is influenced by two factors: metabolic demand
and oxygen supply. There are three regions within the kidney in which there is an …

About one fifth of the cardiac output is di rected to the kidney, mainly for the filtration pro
cess, resulting in an oxygen delivery in excess of 80 ml/min/100 g weight (table 1). This is as …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Because of countercurrent capillary flow, the renal medulla of mammalian kidneys is
perpetually hypoxic, the ambient oxygen tension hovering close to the critical Po2 that limits …

Early medullary hypoxic injury from radiocontrast and indomethacin. We evaluated the acute
changes in cortical and outer medullary oxygen tension and the alterations in renal function …

Objectives: To determine whether there is a decrease in renal cortical or medullary perfusion
and oxygenation in a conscious large animal model of hyperdynamic septic shock with …