The anti-inflammatory effect of vasoactive peptides from soybean protein hydrolysates by mediating serum extracellular vesicles-derived miRNA-19b/CYLD/TRAF6 …

T Song, M Zhou, W Li, M Lv, L Zheng, M Zhao - Food Research International, 2022 - Elsevier
The excessive accumulation of angiotensin II (Ang II) in the vascular microenvironment
promotes vascular dysfunction including vascular endothelial inflammation and remodeling …

[HTML][HTML] The soybean bioactive peptide VHVV alleviates hypertension-induced renal damage in hypertensive rats via the SIRT1-PGC1α/Nrf2 pathway

BCK Tsai, WW Kuo, CH Day, DJY Hsieh… - Journal of Functional …, 2020 - Elsevier
Hypertension triggers oxidative stress, causing dysfunction in organs, including the brain,
heart, and kidney. In this study, we examined the potential renal benefit of the soybean …

Soybean-derived antihypertensive peptide LSW (Leu–Ser–Trp) antagonizes the damage of angiotensin II to vascular endothelial cells through the trans-vesicular …

T Song, M Lv, M Zhou, M Huang… - Journal of Agricultural …, 2021 - ACS Publications
An emerging inference is that vascular cells transfer their biological cargo to recipient cells
by secretion of extracellular vesicles (EVs). This study explored the effects of EVs produced …

Regulatory effects of a pea-derived peptide Leu-Arg-Trp (LRW) on dysfunction of rat aortic vascular smooth muscle cells against angiotensin II stimulation

X Wang, KS Bhullar, H Fan, W Liao… - Journal of agricultural …, 2020 - ACS Publications
Vascular oxidative stress, inflammatory response, and proliferation are crucial mediators of
vascular dysfunction which contribute to the pathology of hypertension. A tripeptide, LRW …

The protective effects of tripeptides VPP and IPP against small extracellular vesicles from angiotensin II-induced vascular smooth muscle cells mediating endothelial …

T Song, M Lv, L Zhang, X Zhang, G Song… - Journal of Agricultural …, 2020 - ACS Publications
Endothelial dysfunction is a common disorder of vascular homeostasis in hypertension
characterized by oxidative stress, malignant migration, inflammatory response, and active …

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously …

K Majumder, G Liang, Y Chen, LL Guan… - Molecular Nutrition & …, 2015 - Wiley Online Library
Scope Egg ovotransferrin‐derived angiotensin converting enzyme (ACE) inhibitory peptide
IRW was previously shown to reduce blood pressure in spontaneously hypertensive rats …

Tripeptide Leu-Ser-Trp regulates the vascular endothelial cells phenotype switching by mediating the vascular smooth muscle cells-derived small extracellular …

T Song, M Zhou, W Li, L Zheng, J Wu, M Zhao - Molecules, 2022 - mdpi.com
Tripeptide LSW, initially identified as a potent ACE inhibitory peptide from soybean protein,
was recently reported to exert a protective effect against angiotensin II-induced endothelial …

Egg white–derived antihypertensive peptide IRW (Ile‐Arg‐Trp) reduces blood pressure in spontaneously hypertensive rats via the ACE2/ang (1‐7)/mas receptor Axis

W Liao, H Fan, ST Davidge, J Wu - Molecular nutrition & food …, 2019 - Wiley Online Library
Scope It is found in the previous study that egg‐white‐derived antihypertensive peptide Ile‐
Arg‐Trp (IRW) upregulated angiotensin converting enzyme 2 (ACE2) in spontaneously …

Egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) inhibits angiotensin II-stimulated migration of vascular smooth muscle cells via angiotensin type I …

W Liao, H Fan, J Wu - Journal of agricultural and food chemistry, 2018 - ACS Publications
Excessive proliferation, inflammation, oxidative stress, and migration induced by angiotensin
II (Ang II), occurring in vascular smooth muscle cells (VSMCs) during vascular remodelling …

Tripeptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) regulate the proliferation and migration of vascular Smooth muscle cells by interfering Ang II-induced human …

T Song, M Lv, B Sun, L Zheng… - Journal of agricultural and …, 2020 - ACS Publications
Angiotensin II (Ang II), a vasoactive factor in the renin–angiotensin–aldosterone system
(RAAS), can regulate vasoconstriction and promote multiple vascular diseases. In this study …