Chicken Muscle-Derived ACE2 Upregulating Peptide VVHPKESF Inhibits Angiotensin II-Stimulated Inflammation in Vascular Smooth Muscle Cells via the ACE2/Ang …

H Fan, W Liao, ST Davidge, J Wu - Journal of Agricultural and …, 2022 - ACS Publications
This study aimed to evaluate the modulatory effects of four chicken muscle-derived peptides
[VRP, LKY, VRY, and VVHPKESF (V–F)] on angiotensin II (Ang II)-induced inflammation in …

Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNFα-Induced Oxidative Stress and Inflammation via Modulating …

H Fan, KS Bhullar, Z Wang, J Wu - Foods, 2022 - mdpi.com
Soybean is a rich source of high-quality proteins and an excellent food source of bioactive
peptides. A tripeptide, Leu–Ser–Trp (LSW), was previously identified from soybean as an …

Identification and screening of potential ACE2 activating peptides from soybean protein isolate hydrolysate against Ang II-induced endothelial dysfunction

M Zhou, T Song, W Li, M Huang, L Zheng… - Journal of Agricultural …, 2023 - ACS Publications
Angiotensin-converting enzyme 2 (ACE2) is a counterregulator against ACE by converting
angiotensin II (Ang II) to Ang-(1–7), and its down-regulation leads to endothelial dysfunction …

Egg-derived peptide IRW inhibits TNF-α-induced inflammatory response and oxidative stress in endothelial cells

W Huang, S Chakrabarti, K Majumder… - Journal of agricultural …, 2010 - ACS Publications
Oxidative stress and vascular inflammatory response are key mediators of endothelial
dysfunction that leads to cardiovascular diseases. A novel peptide, IRW, was previously …

[HTML][HTML] An ACE-inhibitory peptide derived from maize germ antagonizes the Angiotensin II-induced dysfunction of HUVECs via the PI3K/Akt/eNOS signaling pathway

Q Li, K Liu, Z Gao, MT Rashid - Journal of Functional Foods, 2024 - Elsevier
Our previous work identified an ACE inhibitory peptide (ACEIP) with a sequence of LPGP
from maize germ protein. In this study, by employing Ang II-induced Human Umbilical Vein …

Protective Effect of Vitexin Against IL‐17‐Induced Vascular Endothelial Inflammation Through Keap1/Nrf2‐Dependent Signaling Pathway

T Gan, Q Xing, N Li, Z Deng, C Pan… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Vitexin, a C‐glycosylated flavonoid, is abundant in food sources and has potential
health‐beneficial properties. However, the targets for its beneficial effects remain largely …

Tripeptide IRW Improves AMPK/eNOS Signaling Pathway via Activating ACE2 in the Aorta of High-Fat-Diet-Fed C57BL/6 Mice

F Ashkar, KS Bhullar, X Jiang, J Wu - Biology, 2023 - mdpi.com
Simple Summary Metabolic syndrome refers to a cluster of various risk factors commonly
associated with cardiovascular diseases and diabetes. Upregulation of angiotensin …

Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction

Q Zhao, J Yang, B Liu, F Huang… - Molecular Medicine …, 2019 - spandidos-publications.com
Perivascular adipose tissue (PVAT) is considered to serve a vital role during the
development of endothelial dysfunction. The current study investigated the effect of …

Egg white protein hydrolysate decreased blood pressure via the competing endogenous RNA regulatory networks in female spontaneously hypertensive rats

W Liao, X Cao, T Yu, K Lu, H Xia, S Wang, G Sun… - Food & Function, 2023 - pubs.rsc.org
Despite numerous studies having reported the effects and mechanisms of antihypertensive
peptides including peptides derived from egg white proteins, the role of peptides in a female …

The protective effect of hydroxytyrosol acetate against inflammation of vascular endothelial cells partly through the SIRT6-mediated PKM2 signaling pathway

F Yao, G Yang, Y Xian, G Wang, Z Zheng, Z Jin, Y Xie… - Food & function, 2019 - pubs.rsc.org
Hydroxytyrosol acetate (HT-AC), a polyphenolic compound in olive oil, exerts an anti-
inflammatory effect on murine collagen-induced arthritis. However, the effect of HT-AC on …