[HTML][HTML] Geraniin ameliorates hypertensive vascular remodelling in a diet-induced obese animal model through antioxidant and anti-inflammatory effects

BH Goh, HS Cheng, PTAPA Alexandra, KN Ting… - Nutrients, 2023 - mdpi.com
Geraniin, an ellagitannin, has shown a potent blood pressure-lowering effect in vivo.
Therefore, this study aims to further characterize the ability of geraniin to attenuate …

Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II‐Induced Inflammation in Vascular Smooth Muscle Cells

S Zeng, L Yang, C Hong, H Lu, Q Yan… - Mediators of …, 2018 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) has a potent protective action on the
cardiovascular system; however, little is known about the role of CGRP in angiotensin II …

MicroRNA-451 inhibits vascular smooth muscle cell migration and intimal hyperplasia after vascular injury via Ywhaz/p38 MAPK pathway

W Zhang, D Liu, X Han, J Ren, P Zhou… - Experimental Cell …, 2019 - Elsevier
Increasing evidence has indicated that intimal hyperplasia is a common event in the
pathophysiology of many vascular diseases including atherosclerosis (AS). Recently …

[HTML][HTML] MicroRNA-122-5p aggravates angiotensin II-mediated myocardial fibrosis and dysfunction in hypertensive rats by regulating the Elabela/Apelin-APJ and …

J Song, Z Zhang, Z Dong, X Liu, Y Liu, X Li… - Journal of …, 2022 - Springer
Hypertension is the leading risk factor for cardiovascular disorders. This study aimed to
explore roles of microRNA (miR)-122-5p in hypertension. Angiotensin II (Ang II; 1.5 …

Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN

Y Liu, L Liu, Y Jia, Y Sun, F Ma - Bioscience Reports, 2019 - portlandpress.com
The present study aims to investigate the mechanism of miR-15a-5p in the atherosclerotic
(AS) inflammatory response and arterial injury improvement in diabetic rats by regulating …

[HTML][HTML] Zein hydrolysate and its peptides exert anti-inflammatory activity on endothelial cells by preventing TNF-α-induced NF-κB activation

Q Liang, M Chalamaiah, W Liao, X Ren, H Ma… - Journal of Functional …, 2020 - Elsevier
Vascular inflammation and oxidative stress are the major causes of endothelial dysfunction
leading to cardiovascular disease. Previously, we have reported the anti-inflammatory …

[HTML][HTML] Recent findings on the cellular and molecular mechanisms of action of novel food-derived antihypertensive peptides

IU Okagu, TPC Ezeorba, EC Aham… - Food chemistry …, 2022 - Elsevier
Hypertension impacts negatively on the quality of life of sufferers, and complications
associated with uncontrolled hypertension are life-threatening. Hence, many research efforts …

MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 …

JJ Song, M Yang, Y Liu, JW Song, J Wang… - European journal of …, 2020 - Elsevier
Abnormal aortic adventitial fibroblasts (AFs) play essential roles in the development of
vascular remodeling and disorders. Previous studies revealed that microRNA-122 (miR …

Egg white protein ovotransferrin-derived IRW (Ile-Arg-Trp) inhibits LPS-induced barrier integrity dysfunction and inflammation in Caco-2 cells

X Bao, J Wu - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Tripeptide IRW derived from egg ovotransferrin was initially identified to be an inhibitor of
angiotensin-converting enzyme. Later, IRW has been shown to possess various …

Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis

LI Qiang, GUO Lei, W Jian, TAO Shengjun… - Chinese Journal of …, 2023 - Elsevier
Mesenchymal stem cell (MSC)-derived exosomes (Exos) were reported to a prospective
candidate in accelerating diabetic wound healing due to their pro-angiogenic effect. MSCs …