Background: Proteases play important roles in the regulation of many physiological
processes, and protease inhibitors have become one of the important drug classes …

The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …

This review describes the clinical status (based on available information) of experimental
drugs that inhibit enzymes called proteases, or more precisely a sub-class of proteases …

The replication of numerous pathogenic viruses depends on host proteases, which therefore
emerged as potential antiviral drug targets. In some cases, eg, for influenza viruses, their …

Proteolytic enzymes are ubiquitous in all organisms and constitute 2–4% of the encoded
gene products. They are critical for diverse biological processes such as digestion, blood …

This chapter describes the various sources (with an emphasis on microbial sources),
classification, mechanisms of inhibition, purification, characterization, and applications of …

Relatively few design principles underlie the mechanisms of inhibition of a myriad range of
protease inhibitors. Protease inhibitors tend to be competitive and to compete with substrate …

Members of the protease families discussed in this issue are of great interest for different
therapeutic areas tackling contemporary afflictions of mankind such as cardiovascular …

Proteases are enzymes produced by various living organisms and these enzymes help to
cleave proteins into smaller fragments. They are widely involved in biological activities such …

Third RSC-SCI Symposium on Proteinase Inhibitor Design: Proteinase 2002, held May 13-
14, 2002, in London, United Kingdom, drew an audience of about 140 scientists to the SCI's …