Using genomics to understand antimicrobial resistance and transmission in Neisseria gonorrhoeae

L Sánchez-Busó, SR Harris - Microbial genomics, 2019 - microbiologyresearch.org
Gonorrhoea infections are on the increase and strains that are resistant to all antimicrobials
used to treat the disease have been found worldwide. These observations encouraged the …

Differential response of human monocytes to Neisseria gonorrhoeae variants expressing pili and opacity proteins

B Knepper, I Heuer, TF Meyer… - Infection and …, 1997 - Am Soc Microbiol
Experiments in vitro suggest that Neisseria gonorrhoeae surface variation plays a key role in
gonococcal pathogenesis by providing the appropriate bacterial phenotypes to go through …

Seminal plasma initiates a Neisseria gonorrhoeae transmission state

MT Anderson, L Dewenter, B Maier, HS Seifert - MBio, 2014 - Am Soc Microbiol
Niche-restricted pathogens are evolutionarily linked with the specific biological fluids that
are encountered during infection. Neisseria gonorrhoeae causes the genital infection …

Neisseria gonorrhoeae: Adaptation and Survival in the Urogenital Tract

AE Jerse - Persistent Bacterial Infections, 2000 - Wiley Online Library
Uncomplicated gonorrhea is most commonly an acute urogenital infection involving the
urethra in men and the endocervix in women of reproductive age. Upon entering the …

Neisseria gonorrhoeae MtrCDE Efflux Pump During In Vivo Experimental Genital Tract Infection in Men and Mice Reveals the Presence of Within-Host Colonization …

A Waltmann, JT Balthazar, AA Begum, N Hua, AE Jerse… - medRxiv, 2023 - medrxiv.org
The MtrCDE efflux pump of Neisseria gonorrhoeae exports a wide range of antimicrobial
compounds that the gonococcus encounters at mucosal surfaces during colonization and …

[HTML][HTML] Neisseria gonorrhoeae NGO2105 Is an Autotransporter Protein Involved in Adhesion to Human Cervical Epithelial Cells and in vivo Colonization

J Huang, Q Zhang, J Chen, T Zhang, Z Chen… - Frontiers in …, 2020 - frontiersin.org
Autotransporters are important virulence factors in the outer membrane of gram-negative
bacteria. Although several autotransporters have been identified in Neisseria meningitidis …

Genetic Manipulation of Neisseria gonorrhoeae

JP Dillard - Current protocols in microbiology, 2011 - Wiley Online Library
The sexually transmitted pathogen, Neisseria gonorrhoeae, undergoes natural
transformation at high frequency. This property has led to the rapid dissemination of …

Seminal plasma promotes Neisseria gonorrhoeae aggregation and biofilm formation

MT Anderson, L Byerly, MA Apicella… - Journal of …, 2016 - Am Soc Microbiol
Neisseria gonorrhoeae causes the human-specific disease gonorrhea and is transmitted
from person to person primarily via sexual contact. During transmission, N. gonorrhoeae is …

Neisseria gonorrhoeae Induces a Tolerogenic Phenotype in Macrophages to Modulate Host Immunity

A Escobar, E Candia, S Reyes-Cerpa… - Mediators of …, 2013 - Wiley Online Library
Neisseria gonorrhoeae is the etiological agent of gonorrhoea, which is a sexually
transmitted disease widespread throughout the world. N. gonorrhoeae does not improve …

Characterization of the effects of iron on Neisseria gonorrhoeae surface protein modulation and host cell interactions

A Oki - 2014 - scholarscompass.vcu.edu
Iron is an essential nutrient that is sequestered by iron-binding proteins in the human host
resulting in a hostile environment for microbes. Neisseria gonorrhoeae, however, can utilize …