Background Epithelial to mesenchymal transition (EMT) induced by hypoxia is one of the
critical causes of treatment failure in different types of human cancers. NF-κB is closely …

Hypoxia is a microenvironmental factor which plays a critical role in tumor development and
chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of …

Prostate cancer is the most commonly diagnosed cancer in men and the second leading
cause of cancer death. Hypoxia is an environmental stimulus that plays an important role in …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …

Hypoxia activates genetic programs that facilitate cell survival; however, in cancer, it may
promote invasion and metastasis. Although the exact mechanisms driving hypoxia-induced …

Tumor metastasis is accompanied by a two‑stage process of epithelial-to-mesenchymal
transition (EMT) and mesenchymal-to-epithelial transition (MET). Currently, the exact …

Hypoxia is known to promote malignant progression and to induce chemoresistance in
cancer. However, the exact mechanisms driving hypoxia induced malignance remain …

Cancer-associated fibroblasts (CAF) are a major cell type in the stroma of solid tumors and
can exert both tumor-promoting and tumor-restraining functions. CAF heterogeneity is …

Hypoxia microenvironment widely exists in solid tumor tissues, which is mainly due to the
rapid growth of cells within the tumor more than the speed of capillary in neoplasm, resulting …