The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

The nephron is the functional unit of the kidney, but the mechanism of nephron formation
during human development is unclear. We conducted a detailed analysis of nephron …

The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure
kidney functions, the nephrons possess a highly segmental organization where each …

Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative
inductive process extending over days (mouse) or weeks (human) of kidney development …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

As in most organs, the emerging theme in kidney development is the importance of cross-
talk between several tissues and cell lineages to allow morphogenesis to proceed in a …

The structure of a mammalian kidney is parsed into large collections of polarized nephrons,
and each segment is home to a diverse community of cells that specialize in renal endocrine …

Abnormalities of kidney and urinary tract development are the most common cause of end-
stage kidney failure in childhood in the United States. Over the past 20 years, the advent of …