[图书][B] Targeting ALK: An Explanation for PI3K Inhibition Induced Neuroblastoma Regression
Y Guo - 2020 - search.proquest.com
Neuroblastoma is a neural crest-derived malignancy with high heterogeneity, causing 15%
of cancer-related deaths in children. To date, the rate of long-term cure in children with …
of cancer-related deaths in children. To date, the rate of long-term cure in children with …
Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
Background In neuroblastoma, hyperactivation of the PI3K signaling pathway has been
correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the …
correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the …
[HTML][HTML] Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas
S Fransson, P Kogner, T Martinsson… - Journal of Molecular …, 2013 - Springer
The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma
development where Akt/PKB activation is associated with poor prognosis. PI3K activity …
development where Akt/PKB activation is associated with poor prognosis. PI3K activity …
Targeting PI3K in neuroblastoma
V Spitzenberg, C König, S Ulm, R Marone… - Journal of cancer …, 2010 - Springer
Purpose This work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K)
in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown …
in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown …
Anti-tumor activity of CAL-101, a potent selective inhibitor of the p110Δ isoform of PI3K, in models of human glioblastoma
A Kashishian, S Meadows, B Steiner, B Lannutti - Cancer Research, 2011 - AACR
Abstract Phosphatidylinositol 3-kinase (PI3K) activation and Akt phosphorylation play a
pivotal role in cell proliferation and survival, transducing signals from several cell surface …
pivotal role in cell proliferation and survival, transducing signals from several cell surface …
PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition
HF Zhao, J Wang, HR Jiang, ZP Chen… - Journal of experimental & …, 2016 - Springer
Background Glioblastoma multiforme is the most aggressive malignant primary brain tumor,
characterized by rapid growth and extensive infiltration to neighboring normal brain …
characterized by rapid growth and extensive infiltration to neighboring normal brain …
Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma
K Höland, D Boller, C Hagel, S Dolski, A Treszl… - PloS one, 2014 - journals.plos.org
The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway
is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We …
is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We …
PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma
Neuroblastoma is the most common extracranial cancer in childhood. High-risk
neuroblastoma continues to have a poor prognosis and there is an urgent need to design …
neuroblastoma continues to have a poor prognosis and there is an urgent need to design …
Abstract A18: Selectively targeting PI3K isoforms to treat glioblastoma
KJ Pridham, L Le, S Guo, RT Varghese, Y Liang… - Molecular Cancer …, 2020 - AACR
Abstract The phosphatidylinositide 3-kinase (PI3K) family consists of four catalytic isoforms
(PIK3CA, B, D, and G that encode p110alpha, beta, delta, and gamma, respectively), which …
(PIK3CA, B, D, and G that encode p110alpha, beta, delta, and gamma, respectively), which …
A potential role for the inhibition of PI3K signaling in glioblastoma therapy
S Ströbele, M Schneider, L Schneele, MD Siegelin… - PLoS …, 2015 - journals.plos.org
Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the
most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the …
most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the …