Background–A robust biomarker for predicting and evaluating the response to lung volume
reduction (LVR) interventions remains elusive. We investigated the hypothesis that LVR will …

Static and dynamic hyperinflation are key physiologic abnormalities in patients with
advanced emphysema that contribute to dyspnoea, reduction in exercise performance, poor …

INTRODUCTION: In emphysema, static and dynamic hyperinflation can cause dyspnea and
decreased exercise capacity, leading to significant impairment in quality of life …

Introduction: Bronchscopic lung volume reduction (BLVR) has been shown to improve FEV1
compared to standard treatment. The mechanism of improvement has been attributed to a …

Severe emphysema with hyperinflation presents a therapeutic challenge. Inhaled
medication has limited efficacy in individuals with mechanical constraints to the respiratory …

Introduction: Dynamic hyperinflation (DH) is a major marker of exertional dyspnea in patients
with severe emphysema. We hypothesized that BLVR with EBVs decreases DH. Methods: In …

PURPOSE: The National Emphysema Treatment Trial (NETT) demonstrated that lung
volume reduction surgery (LVRS) resulted in greater improvements in FEV1 and quality of …

Many patients with emphysema remain breathless despite optimal medical therapy.
Nonpharmacological approaches to reduce the volume of hyperinflated lungs include lung …

Observational and randomized studies provide convincing evidence that lung volume
reduction surgery (LVRS) improves symptoms, lung function, exercise tolerance, and life …

Lung volume reduction surgery (LVRS) improves the fit of severely hyperinflated
emphysematous lungs to the surrounding chest cavity and thereby improves respiratory …