Abstract Interleukin-6 (IL-6) is considered an inflammatory cytokine, which is involved not
only in most inflammatory states but it also plays a prominent role in inflammation associated …

Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

Abstract Interleukin-6 (IL-6) is an inflammatory cytokine with a well-documented role in
cancer. The cytokine binds to a membrane-bound IL-6 receptor (IL-6R) and this complex …

Abstract Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity,
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic
inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling …

IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense
investigation of its biological activity and function led to the discovery of two different IL-6 …

Cytokines receptors exist in membrane bound and soluble form. A soluble form of the
human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL …

Abstract Interleukin-6 (IL-6) is an inflammatory cytokine with a well-documented role in
inflammation and cancer. The cytokine binds to a membrane bound IL-6 receptor (IL-6R) …

The activation of cells that do not express the membrane bound interleukin-6 6 receptor (IL-
6R) by IL-6 and the soluble IL-6 receptor (sIL-6R) is termed transsignalling. Transsignalling …