Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …

Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also
in the regulation of metabolic, regenerative, and neural processes. In classic signaling …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a wide variety of cells,
exerting growth promotion, growth inhibition, or specific gene expression including cellular …

Soluble gp130 is the natural inhibitor of trans-signaling mediated by the soluble IL-6/IL-6R
complex. In mouse models, recombinant sgp130 has been successfully applied for the …

Interleukin 6 (IL-6) is a cytokine that functions as a trophic and differentiating factor in cells of
many types. Because of its wide-ranging expression and effects, the inappropriate …

Experimental and clinical findings support the essential role of interleukin (IL)-6 in the
pathogenesis of various human cancers and provide a rationale for targeted therapeutic …

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …

Abstract Interleukin-6 (IL-6) is a pro-inflammatory cytokine involved in the pathogenesis of
various autoimmune and chronic inflammatory diseases. Binding of IL-6 to its receptor (IL …

In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …