Aging remains the most pervasive risk factor for a wide range of chronic diseases that afflict
modern societies. In the United States alone, incidence of age-related diseases (eg …

What is the nature of the molecular and cellular mechanisms that drive the aging process is
a puzzling unsolved enigma that has been under debate for decades. Several prominent …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

Recent papers have emphasized the primary role of cellular information management in
biological and evolutionary development. In this framework, intelligent cells collectively …

Highlights•Interconnectivity and homeostatic feedback are fundamental properties of
biological systems.•Specific nodes in the interconnected network of an organism are more …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Cellular senescence is implicated in a wide range of physiological and pathological
conditions throughout an organism's entire lifetime. In particular, it has become evident that …

Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …

We are currently facing particular challenges related to demographic change. People are
reaching very long lives, and the average lifespan has increased considerably since the mid …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …