[HTML][HTML] Genes and Aging: From Bench-to-Bedside
Aging is inevitable, and several structural and functional changes occur in the body with
advanced aging. Aging affects the brain in a variety of ways, the most obvious of which are …
advanced aging. Aging affects the brain in a variety of ways, the most obvious of which are …
The potential of aging rejuvenation
A O'Loghlen - Cell Cycle, 2022 - Taylor & Francis
Aging is a process by which basic cellular functions and tissue homeostasis start to decline
and organs become progressively dysfunctional. Although aging was once considered …
and organs become progressively dysfunctional. Although aging was once considered …
[HTML][HTML] Cellular senescence: a view throughout organismal life
C von Kobbe - Cellular and molecular life sciences, 2018 - Springer
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …
[HTML][HTML] CNS Ageing in health and neurodegenerative disorders
E Kesidou, P Theotokis, O Damianidou… - Journal of Clinical …, 2023 - mdpi.com
The process of ageing is characteristic of multicellular organisms associated with late stages
of the lifecycle and is manifested through a plethora of phenotypes. Its underlying …
of the lifecycle and is manifested through a plethora of phenotypes. Its underlying …
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
A Guerrero, B De Strooper… - Trends in …, 2021 - cell.com
Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
Context‐dependent roles of cellular senescence in normal, aged, and disease states
V Moiseeva, A Cisneros, AC Cobos… - The FEBS …, 2023 - Wiley Online Library
Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue
damage and in age‐related diseases. Through the production of a multicomponent …
damage and in age‐related diseases. Through the production of a multicomponent …
Chipping away at the causes of aging
J Marx - Science, 2000 - science.org
Aging is not kind. Our skin wrinkles, our hair may fall out, our bones and muscles weaken,
and we become increasingly susceptible to a raft of fatal diseases. But despite ever …
and we become increasingly susceptible to a raft of fatal diseases. But despite ever …
[HTML][HTML] The regulation of proteostasis in aging
JX Tang, FH Xiao - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Aging is regarded as a biological process characterized by the progressive loss of
physiological integrity, leading to increased risk for many chronic diseases, such as …
physiological integrity, leading to increased risk for many chronic diseases, such as …