[HTML][HTML] Genes and Aging: From Bench-to-Bedside

WMY Mohamed, C Yi, L Soreq… - Frontiers in Aging …, 2022 - frontiersin.org
Aging is inevitable, and several structural and functional changes occur in the body with
advanced aging. Aging affects the brain in a variety of ways, the most obvious of which are …

The potential of aging rejuvenation

A O'Loghlen - Cell Cycle, 2022 - Taylor & Francis
Aging is a process by which basic cellular functions and tissue homeostasis start to decline
and organs become progressively dysfunctional. Although aging was once considered …

[PDF][PDF] 노화의기전과예방

김재식 - Immune Network, 2001 - immunenetwork.org
Aging is a senescence and defined as a normal physiologic and structural alterations in
almost all organ systems with age. As Leonard Hayflick, one of the first gerontologists to …

[HTML][HTML] Cellular senescence: a view throughout organismal life

C von Kobbe - Cellular and molecular life sciences, 2018 - Springer
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …

[HTML][HTML] CNS Ageing in health and neurodegenerative disorders

E Kesidou, P Theotokis, O Damianidou… - Journal of Clinical …, 2023 - mdpi.com
The process of ageing is characteristic of multicellular organisms associated with late stages
of the lifecycle and is manifested through a plethora of phenotypes. Its underlying …

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

A Guerrero, B De Strooper… - Trends in …, 2021 - cell.com
Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

R Tenchov, JM Sasso, X Wang… - ACS Chemical …, 2023 - ACS Publications
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Context‐dependent roles of cellular senescence in normal, aged, and disease states

V Moiseeva, A Cisneros, AC Cobos… - The FEBS …, 2023 - Wiley Online Library
Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue
damage and in age‐related diseases. Through the production of a multicomponent …

Chipping away at the causes of aging

J Marx - Science, 2000 - science.org
Aging is not kind. Our skin wrinkles, our hair may fall out, our bones and muscles weaken,
and we become increasingly susceptible to a raft of fatal diseases. But despite ever …

[HTML][HTML] The regulation of proteostasis in aging

JX Tang, FH Xiao - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Aging is regarded as a biological process characterized by the progressive loss of
physiological integrity, leading to increased risk for many chronic diseases, such as …