Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing
myeloid progenitors. PHF6 is a chromatin-binding protein mutated in myeloid leukemias …

Acute myeloid leukemia (AML) is a malignant hematologic disease caused by gene
mutations and genomic rearrangements in hematologic progenitors. The PHF6 (PHD finger …

Acute myeloid leukemia is caused by the accumulation of mutations in hematopoietic stem
and myeloid progenitor cells, resulting in increased self-renewal, inhibition of differentiation …

Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2
plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson …

The plant homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute
lymphoblastic leukemia (T-ALL); however, its specific functional role in leukemia …

Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the
uncontrolled expansion of the immature myeloid cells in the hematopoietic system. Current …

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by uncontrolled
division, and differentiation arrest, of hematopoietic stem cells (HSCs) and myeloid …

The PHD finger protein 6 (PHF6) mutations frequently occurred in hematopoietic
malignancies. Although the R274X mutation in PHF6 (PHF6 R274X) is one of the most …

Transcriptional control of hematopoiesis involves complex regulatory networks and
functional perturbations in one of these components often results in malignancies. Loss-of …

Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the
accumulation of immature and abnormally differentiated myeloid cells in bone marrow. Here …