Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing
myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding …

Acute myeloid leukemia (AML) is a malignant hematologic disease caused by gene
mutations and genomic rearrangements in hematologic progenitors. The PHF6 (PHD finger …

Acute myeloid leukemia is caused by the accumulation of mutations in hematopoietic stem
and myeloid progenitor cells, resulting in increased self-renewal, inhibition of differentiation …

The plant homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute
lymphoblastic leukemia (T-ALL); however, its specific functional role in leukemia …

Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2
plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson …

Somatically acquired mutations in PHF6 (plant homeodomain finger 6) frequently occur in
hematopoietic malignancies and often coincide with ectopic expression of TLX3. However …

Epigenetic regulation of gene expression represents an important mechanism in the
maintenance of stem cell function. Alterations in epigenetic regulation contribute to the …

Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the
accumulation of immature and abnormally differentiated myeloid cells in bone marrow. Here …

Recurrent inactivating mutations have been identified in the X-linked plant homeodomain
finger protein 6 (PHF6) gene, encoding a chromatin-binding transcriptional regulator protein …

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by uncontrolled
division, and differentiation arrest, of hematopoietic stem cells (HSCs) and myeloid …