[HTML][HTML] Differential apoptotic response of human cancer cells to organoselenium compounds

M Suzuki, M Endo, F Shinohara, S Echigo… - Cancer chemotherapy …, 2010 - Springer
Abstract Purpose Selenium (Se) compounds are well known to inhibit cell proliferation and
induce cell death in human cancer cells. Respective chemical forms of Se are intracellularly …

Selenium induces a multi‐targeted cell death process in addition to ROS formation

M Wallenberg, S Misra, AM Wasik… - Journal of cellular …, 2014 - Wiley Online Library
Selenium compounds inhibit neoplastic growth. Redox active selenium compounds are
evolving as promising chemotherapeutic agents through tumour selectivity and multi‐target …

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

C Jiang, Z Wang, H Ganther, J Lu - Cancer research, 2001 - AACR
Apoptosis induction may be a mechanism mediating the anticancer activity of selenium. Our
earlier work indicated that distinct cell death pathways are likely involved in apoptosis …

Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways

A Ghose, J Fleming, K El-Bayoumy, PR Harrison - Cancer research, 2001 - AACR
Prospective studies and recent intervention trials suggest that the risk of some cancers,
including respiratory tract cancers, may be inversely related to selenium (SE) intake, and this …

Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species …

T Chen, YS Wong - The international journal of biochemistry & cell biology, 2009 - Elsevier
The role of selenium as potential cancer chemopreventive and chemotherapeutic agents
has been supported by epidemiological, preclinical and clinical studies. Although cell …

Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition

AR Choi, MJ Jo, MJ Jung, HS Kim, S Yoon - European Journal of …, 2015 - Elsevier
The purpose of this study was to identify conditions that will increase the sensitivity of drug-
resistant cancer cells. Selenium derivatives have been shown to present anti-cancer …

Investigation of the selenium metabolism in cancer cell lines

K Lunøe, C Gabel-Jensen, S Stürup, L Andresen… - Metallomics, 2011 - academic.oup.com
The aim of this work was to compare different selenium species for their ability to induce cell
death in different cancer cell lines, while investigating the underlying chemistry by speciation …

Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium

RJ Jariwalla, B Gangapurkar… - British journal of nutrition, 2008 - cambridge.org
Selenium is an important trace element with anti-cancer properties. In the present study, the
apoptosis-inducing effects of organic selenium derivatives, namely methyl-l-selenocysteine …

Selenium compounds and apoptotic modulation: a new perspective in cancer therapy

C Sanmartin, D Plano, JA Palop - Mini reviews in medicinal …, 2008 - ingentaconnect.com
Recent epidemiological studies have demonstrated that selenium may be an effective
chemopreventive and anticancer agent with a broad spectrum against several human …

[HTML][HTML] Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells

M Suzuki, M Endo, F Shinohara, S Echigo… - Cancer chemotherapy …, 2011 - Springer
Purpose Although selenium compounds possess chemotherapeutic features by inducing
apoptosis in cancer cells with trivial side effects on normal cells, the mechanisms underlying …