[HTML][HTML] In Vitro Inhibition of Colorectal Cancer Gene Targets by Withania somnifera L. Methanolic Extracts: A Focus on Specific Genome Regulation

JM Macharia, DO Pande, A Zand, F Budán… - Nutrients, 2024 - mdpi.com
An approach that shows promise for quickening the evolution of innovative anticancer drugs
is the assessment of natural biomass sources. Our study sought to assess the effect of W …

[HTML][HTML] Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management

JM Macharia, Z Káposztás, RL Bence - Pharmaceuticals, 2023 - mdpi.com
Research into tumorigenic pathways can aid in the development of more efficient cancer
therapies and provide insight into the physiological regulatory mechanisms employed by …

Withania somnifera: From prevention to treatment of cancer

DL Palliyaguru, SV Singh… - Molecular nutrition & food …, 2016 - Wiley Online Library
The identification of bioactive molecules that have potential to interrupt carcinogenesis
continues to garner research interest. In particular, molecules that have dietary origin are …

Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice

B Padmavathi, PC Rath, AR Rao… - Evidence‐Based …, 2005 - Wiley Online Library
We evaluated the cancer chemopreventive efficacy of the Withania somnifera root, which
has been used in the Indian traditional medicine system for many centuries for the treatment …

[HTML][HTML] Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics

VK Kashyap, G Peasah-Darkwah, A Dhasmana… - Pharmaceutics, 2022 - mdpi.com
Chemotherapy is one of the prime treatment options for cancer. However, the key issues
with traditional chemotherapy are recurrence of cancer, development of resistance to …

[HTML][HTML] Physalis peruviana-Derived 4β-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo

ZN Ye, F Yuan, JQ Liu, XR Peng, T An, X Li, LM Kong… - Molecules, 2019 - mdpi.com
Deregulation of the Wnt signaling pathway leads to colorectal cancer progression. Natural
dietary compounds serve as promising candidates for development as chemopreventive …

Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer

A Saggam, G Tillu, S Dixit, P Chavan-Gautam… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Withania somnifera (L.) Dunal (WS) is one of the
moststudied Rasayana botanicals used in Ayurveda practice for its immunomodulatory, anti …

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

N Yadav, S Tripathi, NS Sangwan - Phytotherapy Research, 2024 - Wiley Online Library
Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has
been used since ancient times to cure various health ailments. Withania somnifera is rich in …

[HTML][HTML] Regulatory activities of Warbugia ugandensis ethanolic extracts on colorectal cancer-specific genome expression dose-dependently

JM Macharia, RW Mwangi, I Szabó, A Zand… - Biomedicine & …, 2023 - Elsevier
The evaluation of natural biomass sources is a promising strategy in accelerating the
development of novel anti-cancer medications. Our study aimed to evaluate the activity of W …

[HTML][HTML] Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'

AB Henley, L Yang, KL Chuang, M Sahuri-Arisoylu… - PLoS …, 2017 - journals.plos.org
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and
antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial …