Structural Basis of Gene Regulation by the Transcription Factors Tfcp2l1 and Tfcp2

J Wang - 2022 - refubium.fu-berlin.de
Mammalian Tfcp2l1 and Tfcp2 are grouped into the CP2 subfamily of the grainyhead/CP2
(Grh/CP2) transcription factors involved in pluripotency maintenance and self-renewal of …

[HTML][HTML] Structural and functional insights into CP2c transcription factor complexes

SH Son, MY Kim, E Jo, VN Uversky… - International Journal of …, 2022 - mdpi.com
CP2c, also known as TFCP2, α-CP2, LSF, and LBP-1c, is a prototypic member of the
transcription factor (TF) CP2 subfamily involved in diverse ubiquitous and tissue/stage …

TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer

N Kaushik, A Jaiswal, P Bhartiya, EH Choi… - Cancer and Metastasis …, 2024 - Springer
Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic
landscape associated with cancer, with a minimal number of genes exhibiting dual-context …

TFCP2/TFCP2L1/UBP1 transcription factors in cancer

G Kotarba, E Krzywinska, AI Grabowska, A Taracha… - Cancer letters, 2018 - Elsevier
The TFCP2/Grainyhead family of transcription factors is divided into two distinct subfamilies,
one of which includes the Grainyhead-like 1-3 (GRHL1-3) proteins and the other consists of …

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family

Q Ming, Y Roske, A Schuetz, K Walentin… - Nucleic acids …, 2018 - academic.oup.com
Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …

Structures of CTCF–DNA complexes including all 11 zinc fingers

J Yang, JR Horton, B Liu, VG Corces… - Nucleic acids …, 2023 - academic.oup.com
The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …

Structure, function, and cell cycle-dependent proteostasis of the transcription factor CP2c complexes

손승한 - 2023 - repository.hanyang.ac.kr
The protein homeostasis (proteostasis) is crucial for the regulation of cellular and tissue
metabolism. Homeostasis is regulated very tightly by various regulatory proteins, including …

Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors

K Liu, Y Xiao, L Gan, W Li, J Zhang… - Nucleic Acids …, 2023 - academic.oup.com
The TFAP2 family regulates gene expression during differentiation, development, and
organogenesis, and includes five homologs in humans. They all possess a highly conserved …

CTCF as a multifunctional protein in genome regulation and gene expression

김소미, 유남경, 강봉균 - Experimental and Molecular Medicine, 2015 - dbpia.co.kr
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as
a transcription factor. It can function as a transcriptional activator, a repressor or an insulator …

[HTML][HTML] CTCF as a multifunctional protein in genome regulation and gene expression

S Kim, NK Yu, BK Kaang - Experimental & molecular medicine, 2015 - nature.com
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as
a transcription factor. It can function as a transcriptional activator, a repressor or an insulator …