The TFAP2 family regulates gene expression during differentiation, development, and
organogenesis, and includes five homologs in humans. They all possess a highly conserved …

CCCTC-binding factor (CTCF) is a key regulator of nuclear chromatin structure and gene
regulation. The impact of CTCF on transcriptional output is highly varied, ranging from …

We have previously shown that the widely expressed human transcription factor TCF11/LCR-
F1/Nrf1 interacts with small Maf proteins and binds to a subclass of AP1-sites. Such sites are …

The C-terminal domain of the eukaryotic transcriptional cofactor PC4 (PC4 CTD) is known to
bind with nanomolar affinity to single-stranded (ss) DNA. Here, NMR is used to study DNA …

The function of the CCCTC-binding factor (CTCF) in the organization of the genome has
become an important area of investigation, but the mechanisms of how CTCF dynamically …

We evaluated DNA binding of the B-HLH family members TCF4 and USF1 using protein
binding microarrays (PBMs) containing double-stranded DNA probes with cytosine on both …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

DNA structuring proteins such as CTCF facilitate DNA loop formation and are presumed to
be among the major determinants of eukaryotic genome structure. Recent studies, including …

The RNA polymerase III initiation factor TFIIIB is assembled onto DNA through interactions
involving the Tfc4 subunit of the assembly factor TFIIIC and two subunits of TFIIIB, Brf1 and …

Background CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is
involved in chromatin organization, local histone modifications, and RNA polymerase II …