[HTML][HTML] Amyloid-β regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes

M Maulik, L Vasan, A Bose, SD Chowdhury… - Journal of Biological …, 2020 - ASBMB
Altered expression and function of astroglial gap junction protein connexin 43 (Cx43) has
increasingly been associated to neurotoxicity in Alzheimer disease (AD). Although earlier …

[HTML][HTML] Altered expression of glial gap junction proteins Cx43, Cx30, and Cx47 in the 5XFAD model of Alzheimer's disease

S Angeli, I Kousiappa, M Stavrou… - Frontiers in …, 2020 - frontiersin.org
Glial gap junction proteins, called connexins (Cxs), form gap junctions in the central nervous
system (CNS) to allow the bidirectional cytosolic exchange of molecules between adjacent …

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia

MA Retamal, N Froger, N Palacios-Prado… - Journal of …, 2007 - Soc Neuroscience
Astrocytes have a role in maintaining normal neuronal functions, some of which depend on
connexins, protein subunits of gap junction channels and hemichannels. Under …

Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer's disease

JI Nagy, W Li, EL Hertzberg, CA Marotta - Brain research, 1996 - Elsevier
The distribution of the astrocytic gap junctional protein, connexin43 (Cx43) was compared
immunohistochemically with that of amyloid plaques in Alzheimer's Disease (AD) brain. By …

Neuronal activity drives astroglial connexin 30 in perisynaptic processes and shapes its functions

G Ghézali, F Vasile, N Curry, M Fantham… - Cerebral …, 2020 - academic.oup.com
Astrocytes play key roles in brain functions through dynamic interactions with neurons. One
of their typical features is to express high levels of connexins (Cxs), Cx43 and Cx30, the gap …

Astrocyte‐restricted disruption of connexin‐43 impairs neuronal plasticity in mouse barrel cortex

Y Han, H Yu, M Sun, Y Wang, W Xi… - European Journal of …, 2014 - Wiley Online Library
There is intensive gap‐junctional coupling between glial processes, but their significance in
sensory functions remains unknown. C onnexin‐43 (C x43), a major component of astrocytic …

Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes

D May, O Tress, G Seifert, K Willecke - Journal of Neuroscience, 2013 - Soc Neuroscience
Panglial networks are essential for normal physiology in the CNS, and the function of distinct
connexins participating in these networks is not well understood. We generated Connexin32 …

Proteomic analysis of astroglial connexin43 silencing uncovers a cytoskeletal platform involved in process formation and migration

S Olk, A Turchinovich, M Grzendowski, K Stühler… - Glia, 2010 - Wiley Online Library
Abstract Connexin43 (Cx43) is the most abundant gap junction protein of the brain, where it
is predominantly expressed in astrocytes. Recent studies imply a role of Cx43 in the …

Astrocyte cultures from conditional connexin43‐deficient mice

M Theis, D Speidel, K Willecke - Glia, 2004 - Wiley Online Library
Abstract Connexin43 (Cx43) mainly provides the molecular basis for astrocytic gap
junctions. Interastrocytic coupling is thought to mediate extracellular ion homeostasis, long …

Connexin43 null mice reveal that astrocytes express multiple connexins

R Dermietzel, Y Gao, E Scemes, D Vieira… - Brain Research …, 2000 - Elsevier
The gap junction protein connexin43 (Cx43) is the primary component of intercellular
channels in cardiac tissue and in astrocytes, the most abundant type of glial cells in the …