Bioactive indolizidine alkaloids

SM Colegate, PR Dorling - Handbook of Plant and Fungal …, 2020 - taylorfrancis.com
Complete hydrogen saturation of the indolizine system produces the indolizidine
(octahydroindolizine) heterocyclic ring system. Swainsonine, the first water-soluble …

Swainsonine: a toxic indolizidine alkaloid from the Australian Swainsona species

SM Colegate, PR Dorling… - Toxicology of Plant and …, 1991 - books.google.com
Intoxication of farm stock following ingestion of plants belonging to the Swainsona genus
has never been of major national economic significance in Australia, but has placed a …

Novel pyrrolizidine alkaloid

AD Elbein, JE Tropea - US Patent 5,021,427, 1991 - Google Patents
Investigations relating to the present invention were supported in part by research grant HL-
17783 from the National Institutes of Health (United States Department of Health and Human …

Indolizidine and quinolizidine alkaloids

JP Michael - Natural product reports, 1998 - pubs.rsc.org
Bioactive indolizidine alkaloids isolated from fungal and plant sources have been surveyed
in an important new review that constitutes the opening chapter in a larger work on natural …

Synthetic methods for the stereoisomers of swainsonine and its analogues

A El Nemr - Tetrahedron, 2000 - Elsevier
The (1S, 2R, 8R, 8aR)-1, 2, 8-trihydroxyindolizidine,(2)-swainsonine (1), which was first
isolated from the fungus Rhizoctonia leguminicola1 and later found in the Australian plant …

Swainsonine: a toxic indolizidine alkaloid

PR Dorling, SM Colegate… - Toxicants of Plant Origin, 1989 - books.google.com
Swainsonine is an indolizidine alkaloid which was originally identified as the toxic
constituent of the Australian legume Swainsona canescens.'It has since been isolated from …

Identification of the Glycosidase Inhibitors Swainsonine and Calystegine B2 in Weir Vine (Ipomoea sp. Q6 {aff. calobra}) and Correlation with Toxicity

RJ Molyneux, RA McKenzie… - Journal of Natural …, 1995 - ACS Publications
The polyhydroxy alkaloid glycosidase inhibitors swainsonine [1] and calystegine B2 [6] have
been identified as constituents of the seeds of the Australian plant Ipomoea sp. Q6 [aff …

Derivatives of swainsonine and their use as therapeutic agents

J Carver, R Shah - US Patent 5,962,467, 1999 - Google Patents
Swainsonine (SW) is an indolizidine alkaloid found in Australian SwainsOna canescenS
(Colegate et al., Aust J Chem 32: 2257–2264, 1979), North American plants of the genera …

Australine, a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australe

RJ Molyneux, M Benson, RY Wong… - Journal of Natural …, 1988 - ACS Publications
Australine [1], a tetrahydroxy pyrrolizidine alkaloid with a unique sub-stitution pattern, has
been isolated from seeds of Castanospermum australeand shown to be a po-tent and …

(1S, 2R, 8aS)-1, 2-Dihydroxyindolizidine formation by Rhizoctonia leguminicola, the fungus that produces slaframine and swainsonine

TM Harris, CM Harris, JE Hill… - The Journal of …, 1987 - ACS Publications
The title diol (6a) has been shown to be a metabolite of Rhizoctonia leguminicola, the
fungus that produces two toxic indolizidine alkaloids, swainsonine (1) and slaframine (2) …