The physiological functions of many vital tissues and organs continue to mature after birth,
but the genetic mechanisms governing this postnatal maturation remain an unsolved …

Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell
therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells …

Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth
and maturation to accelerate development of therapies for diabetes. After birth, islet cell …

Since their discovery nearly five decades ago, molecular scaffolds belonging to the 14-3-3
protein family have been recognized as pleiotropic regulators of diverse cellular and …

Six1 is one of the transcription factors that act as master regulators of development and are
frequently dysregulated in cancers. However, the role of Six1 in pancreatic cancer is not …

Abstract Background The Six1 homeobox gene is highly expressed in the embryonic
mammary gland, continues to be expressed in early postnatal mammary development, but is …

Precise spatiotemporal regulation of the SIX1 homeoprotein is required to coordinate vital
tissue development, including myogenesis. Whereas SIX1 is downregulated in most tissues …

Aims/hypothesis Diabetes is characterised by pancreatic beta cell death and dysfunction,
resulting from unbalanced pro-survival and pro-death signalling. The 14-3-3 proteins are …

Muscle satellite cells are essential for muscle growth and regeneration and their
morphology, behavior and gene expression have been extensively studied. However, the …

The Six1 homeoprotein plays a critical role in expanding progenitor populations during
normal development via its stimulation of proliferation and inhibition of apoptosis …