The development of fibrosis in both the glomerulus and tubulointerstitium is a hallmark of
most renal diseases. Numerous pathological mediators and mechanisms are known to play …

Renal fibrosis (RF) is the final step in chronic kidney disease (CKD) that is represented by
abundant extracellular matrix (ECM) components, tubular atrophy and inflammatory cell …

The components of the renin-angiotensin system (RAS) in progressive renal disease have
been extensively investigated, indicating multiple actions beyond hemodynamic and …

Angiotensin (Ang) II, the main peptide of the renin angiotensin system (RAS), is a renal
growth factor, inducing hyperplasia/hypertrophy depending on the cell type. This vasoactive …

The response to injury involves the activation of a vast array of adaptive mechanisms
designed not only to maintain homeostasis but also to induce tissue repair. In lower animals …

Angiotensin II (AngII) participates in the pathogenesis of renal diseases, through the
regulation of two key processes inflammation and fibrosis. AT1 and AT2 are the main …

Inhibitors of the renin-angiotensin-aldosterone system attenuate glomerulosclerosis and
interstitial fibrosis. Although the mechanisms underlying their antifibrotic effects are complex …

Chronic activation of renin-angiotensin system (RAS) greatly contributes to renal fibrosis and
accelerates the progression of chronic kidney disease; however, the underlying molecular …

Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …

The renin-angiotensin system (RAS), beside its pivotal role in the regulation of extracellular
volume and systemic blood pressure, also functions at the intercrine, autocrine and …