Obese women, on average, give birth to babies with high fat mass. Placental lipid
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …

Placentas of obese women have low mitochondrial β-oxidation of fatty acids (FA) and
accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing …

Background: Obesity before pregnancy is associated with impaired metabolic status of the
mother and the offspring later in life. These adverse effects have been attributed to …

Fatty acid metabolism and oxidation capacity in the placenta, which likely affects the rate
and composition of lipid delivered to the fetus remains poorly understood. Long chain …

Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal
obesity is associated with a specific proinflammatory, endocrine and metabolic phenotype …

Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated
with pregnancy complications such as preeclampsia and gestational diabetes, and offspring …

Abstract Knowledge of the consequences of maternal obesity in human placental fatty acids
(FA) transport and metabolism is limited. Animal studies suggest that placental uptake of …

During pregnancy, maternal plasma fatty acids are critically required for cell growth and
development, cell signaling, and the development of critical structural and functional aspects …

Objective Maternal obesity increases the incidence of excess adiposity in newborns,
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …

Introduction Placental fatty acid (FA) uptake and metabolism depend on maternal supply
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …