[HTML][HTML] Exercise-boosted mitochondrial remodeling in Parkinson's disease

JC Magaña, CM Deus, M Giné-Garriga, J Montané… - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is a movement disorder characterized by the progressive
degeneration of dopaminergic neurons resulting in dopamine deficiency in the striatum …

[HTML][HTML] Mitochondrial homeostasis and signaling in Parkinson's disease

A Scorziello, D Borzacchiello, MJ Sisalli… - Frontiers in Aging …, 2020 - frontiersin.org
The loss of dopaminergic (DA) neurons in the substantia nigra leads to a progressive, long-
term decline of movement and other non-motor deficits. The symptoms of Parkinson's …

[HTML][HTML] The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson's Disease

J Li, Y Xu, T Liu, Y Xu, X Zhao, J Wei - International Journal of Molecular …, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common rapidly progressive
neurodegenerative disease and has serious health and socio-economic consequences …

[HTML][HTML] Mitochondria and Parkinson's disease: clinical, molecular, and translational aspects

M Borsche, SL Pereira, C Klein… - Journal of Parkinson's …, 2021 - content.iospress.com
Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Emerging concepts of mitochondrial dysfunction in Parkinson's disease progression: Pathogenic and therapeutic implications

L Rani, AC Mondal - Mitochondrion, 2020 - Elsevier
Mitochondria are very dynamic organelle which plays a multifactorial role for a broad range
of physiological processes inside the cell to maintain neural circuit integrity. They are …

Mitochondrial dysfunction and Parkinson's disease: pathogenesis and therapeutic strategies

S Moradi Vastegani, A Nasrolahi, S Ghaderi… - Neurochemical …, 2023 - Springer
Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

[HTML][HTML] Mitochondrial dysfunction in Parkinson's disease: from mechanistic insights to therapy

XY Gao, T Yang, Y Gu, XH Sun - Frontiers in aging neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Disease mechanisms as Subtypes: Mitochondrial and bioenergetic dysfunction

P Gonzalez-Rodriguez, E Zampese… - Handbook of Clinical …, 2023 - Elsevier
Parkinson disease (PD) is the second most common neurodegenerative disease in the
world. Despite its enormous human and societal cost, there is no disease-modifying therapy …

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

[HTML][HTML] Understanding the Multiple role of mitochondria in Parkinson's disease and related disorders: Lesson from genetics and protein–interaction network

V Nicoletti, G Palermo, E Del Prete… - Frontiers in Cell and …, 2021 - frontiersin.org
As neurons are highly energy-demanding cell, increasing evidence suggests that
mitochondria play a large role in several age-related neurodegenerative diseases. Synaptic …