Human natural killer (NK) cells are found in virtually all tissues where they act as a first line
defense against malignant and virally infected cells. The development of NK cells from …

Natural killer (NK) cells are innate immune cells that reside within tissue and circulate in
peripheral blood. As such, they interact with a variety of complex microenvironments, yet …

Natural killer (NK) cells develop from CD34+ progenitors in a stage-specific manner defined
by changes in cell surface receptor expression and function. Secondary lymphoid tissues …

While distinct stages of natural killer (NK) cell development have been defined, the
molecular interactions that shape human NK cell maturation are poorly understood. Here we …

NK cells are innate immune cells that reside within tissue and circulate in peripheral blood.
They interact with a variety of microenvironments, yet how NK cells engage with these varied …

A better understanding of human NK cell development in vivo is crucial to exploit NK cells for
immunotherapy. Here, we identified seven distinctive NK cell developmental stages in bone …

Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

Natural killer (NK) cells are effector cells of the innate immune system that are responsible
for mediating cellular cytotoxicity against virally infected or neoplastically transformed cells …

Human natural killer (NK) cells develop in secondary lymphoid tissues (SLTs) through
distinct stages. We identified two SLT lineage (Lin)− CD34− CD117+/− CD94+ CD16−" …

Limitations in neonatal natural killer (NK) cell responses may be associated with the less
efficient newborn capacity to solve viral infections. Although these limitations have been …