Cancer is the leading cause of death globally with an urgent need to find more effective
approaches for prevention and treatment. mRNA vaccine is a promising vaccine platform …

An mRNA with unmodified nucleosides induces type I interferons (IFN-I) through the
stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for …

Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …

mRNA vaccines are promising for cancer treatment. Efficient delivery of mRNAs encoding
tumor antigens to antigen-presenting cells (APCs) is critical to elicit anti-tumor immunity …

Intracellular delivery of messenger RNA (mRNA)-based cancer vaccines have shown great
potential to activate antitumor immune response for cancer prevention and therapy. In vivo …

The targeted delivery of messenger RNA (mRNA) to desired organs remains a great
challenge for in vivo applications of mRNA technology. For mRNA vaccines, the targeted …

This study reports on the design of mRNA and adjuvant-loaded lipid nanoparticles for
therapeutic cancer vaccination. The use of nucleoside-modified mRNA has previously been …

RNA therapeutics have received much attention in the development of anti-cancer therapies.
Among them, synthetic mRNA (IVT mRNA) was investigated for cancer immunotherapy due …

Evaluation of: Fotin-Mleczek M, Duchardt KM, Lorenz C et al.: Messenger RNA-based
vaccines with dual activity induce balanced TLR7-dependent adaptive immune responses …

Messenger RNA (mRNA)-based cancer vaccine has become a popular approach for
developing personalized and effective antitumor immunotherapy. To achieve robust …