Besides anti-viral functions, Type I IFN expresses potent anti-inflammatory properties and is
being widely used to treat certain autoimmune conditions, such as multiple sclerosis (MS). In …

The key to the treatment of multiple sclerosis (MS) is to promote the transition from
inflammation-induced demyelination to remyelination. Polarization of microglia towards M1 …

Type I interferons (IFNs) are major mediators of innate immunity, with well-known antiviral,
antiproliferative, and immunomodulatory properties. A growing body of evidence suggests …

Although contributing to inflammatory responses and to the development of certain
autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral …

Excessive activation of T cells and microglia represents a hallmark of the pathogenesis of
human multiple sclerosis (MS). However, the regulatory molecules overactivating these …

Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous
system (CNS) with unknown etiology. Interferon-β (IFN-β), a member of the type I IFN family …

Abstract Type I IFNs (IFN-α and IFN-β) and type II IFN (IFN-γ) mediate both regulation and
inflammation in multiple sclerosis, neuromyelitis optica, and in experimental autoimmune …

IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but
understanding the mechanisms underlying its beneficial effects remains incomplete. We …

Interferon-induced tetrapeptide repeat (IFIT) family proteins are an important component of
the antiviral immune response. There are four known members of the human IFIT family …

Interferon‐induced transmembrane protein 3 (IFITM3) ıplays a crucial role in the antiviral
responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system …