Transaldolase (TAL) is an enzyme in the pentose phosphate pathway (PPP) that generates
NADPH for protection against oxidative stress. While deficiency of other PPP enzymes, such …

Although oxidative stress has been implicated in acute acetaminophen-induced liver failure
and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying …

Although oxidative stress has been implicated in acute acetaminophen-induced liver failure
and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying …

Abstract Transaldolase deficiency (MIM#: 606003) is a rare autosomal recessive defect in
the pentose phosphate pathway. Affected individuals are at risk for progressive liver failure …

Transaldolase (TALDO) deficiency (OMIM# 606003), a recently recognized new inborn error
of the pentose phosphate pathway (PPP), has been reported to date in only 10 patients from …

This paper describes the second patient found to be affected with a deficiency of
transaldolase (TALDO1; EC 2.2. 1.2). Clinically, this patient presented in the neonatal period …

Mutations in the transaldolase 1 (TALDO1) gene have been described in a limited number of
cases. Several organs can be affected and clinical manifestations are variable, but often …

Metabolism of glucose through the pentose phosphate pathway (PPP) influences the
development of diverse pathologies. Hemolytic anemia due to deficiency of PPP enzyme …

Transaldolase deficiency is a heterogeneous disorder of carbohydrate metabolism
characterized clinically by dysmorphic features, cutis laxa, hepatosplenomegaly, hepatic …

The signaling networks that mediate cell growth, differentiation, and survival are dependent
on complex metabolic and redox pathways. Metabolism of glucose through the pentose …