Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain
S Sikandar, MS Minett, Q Millet, S Santana-Varela… - Brain, 2018 - academic.oup.com
Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …
pain processes in the peripheral and central nervous system. We have previously shown …
Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain
J Zhao, A Seereeram, MA Nassar, A Levato… - Molecular and Cellular …, 2006 - Elsevier
Conditional mouse knock-outs provide an informative approach to drug target validation
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …
BDNF in sensory neurons and chronic pain
K Obata, K Noguchi - Neuroscience research, 2006 - Elsevier
Neurotrophic factors, which support neuronal survival and growth during development of the
nervous system, have been shown to play significant roles in the transmission of physiologic …
nervous system, have been shown to play significant roles in the transmission of physiologic …
[HTML][HTML] Peripheral brain derived neurotrophic factor precursor regulates pain as an inflammatory mediator
C Luo, XL Zhong, FH Zhou, J Li, P Zhou, JM Xu… - Scientific reports, 2016 - nature.com
The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …
Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord
Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …
peripheral injury, is a major component of many persistent pain states. Here we report that …
Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord
SWN Thompson, DLH Bennett… - Proceedings of the …, 1999 - National Acad Sciences
The primary sensory neurons that respond to noxious stimulation and project to the spinal
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …
[HTML][HTML] The role of the brain-derived neurotrophic factor in chronic pain: links to central sensitization and neuroinflammation
HY Xiong, J Hendrix, S Schabrun, A Wyns… - Biomolecules, 2024 - mdpi.com
Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …
Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation …
R Groth, L Aanonsen - Pain, 2002 - Elsevier
Although known primarily for its role in neuronal development, brain-derived neurotrophic
factor (BDNF) has also recently been implicated in processes mediated by the adult nervous …
factor (BDNF) has also recently been implicated in processes mediated by the adult nervous …
Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation
In the adult mammalian brain, brain-derived neurotrophic factor (BDNF) is critically involved
in long-term synaptic plasticity. Here, we show that supraspinal BDNF-tyrosine kinase …
in long-term synaptic plasticity. Here, we show that supraspinal BDNF-tyrosine kinase …
Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?
J Nijs, M Meeus, J Versijpt, M Moens, I Bos… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …