Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …

Conditional mouse knock-outs provide an informative approach to drug target validation
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …

Neurotrophic factors, which support neuronal survival and growth during development of the
nervous system, have been shown to play significant roles in the transmission of physiologic …

The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …

Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …

The primary sensory neurons that respond to noxious stimulation and project to the spinal
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Although known primarily for its role in neuronal development, brain-derived neurotrophic
factor (BDNF) has also recently been implicated in processes mediated by the adult nervous …

In the adult mammalian brain, brain-derived neurotrophic factor (BDNF) is critically involved
in long-term synaptic plasticity. Here, we show that supraspinal BDNF-tyrosine kinase …

Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …