There is a debate on whether lipid-mediated insulin resistance derives from an increased or
decreased capacity of muscle to oxidize fats. Here, we examine the involvement of muscle …

Context: Skeletal muscle insulin resistance is proposed to result from impaired skeletal
muscle lipid oxidative capacity. However, there is no evidence indicating that muscle lipid …

A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been
proposed as a major factor leading to the accumulation of intramuscular lipids and their …

Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due
to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

During fasting, human skeletal muscle depends on lipid oxidation for its energy substrate
metabolism. This is associated with the development of insulin resistance and a subsequent …

We hypothesized that acute lipid-induced insulin resistance would be attenuated in high-
oxidative muscle of lean trained (LT) endurance athletes due to their enhanced metabolic …

Insulin resistance in skeletal muscle is associated with 1) relative increases in the proportion
of glycolytic and fast-twitch muscle fibers and decreases in the proportion of more oxidative …

abstract Context: Insulin resistance is accompanied by lower lipid oxidation during fasting
and metabolic inflexibility. Whether these abnormalities correlate with mitochondrial content …

Insulin resistance—an impairment in the ability of insulin to appropriately regulate glucose
and lipid metabolism—is an early and key defect associated with weight gain (obesity), type …