Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous
progress in our understanding of B cell development, maturation and function. A number of …

In man and in mouse, B‐cell maturation occurs in steps, first in the bone marrow from
hematopoietic precursors to immature/transitional B cells, then in the periphery from …

The adaptive immune system has developed several highly effective mechanisms in order to
avoid excessive or unwanted reactions and promote resolution of immune activation. An …

Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells
play important roles in innate immunity in contrast to B2 cells that perform the conventional …

The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells
could downregulate the immune system by the production of “inhibitory” antibodies …

Transitional B cells mark the crucial link between bone-marrow (BM) immature and
peripheral mature B cells. Examination reveals unexpected heterogeneity, consisting of …

Since their discovery, B1 B cells' origins and developmental pathways have eluded
characterization. In the past year, focus on B1 B cells has shifted dramatically from …

The initial phases of B cell development depend on interactions between the cell surface
molecules and secreted products of stromal cells with their receptor-ligand partners on …

In contrast to the predominant population of B-2 B cells produced in the bone marrow, B-1 B
cells are a minor population of B lymphocytes that are found in multiple tissues, including the …

This analysis of B cell development as a function of age reveals a relatively widespread
distribution of progenitor B (pro-B), pre-B, and B cells in fetal tissues, and thus supports the …