[HTML][HTML] Gepants—a long way to cure: a narrative review
C Altamura, N Brunelli, M Marcosano, L Fofi… - Neurological …, 2022 - Springer
Calcitonin gene-related peptide (CGRP) is probably the most potent vasodilator in cerebral
circulation. Forty years after its discovery, the new CGRP-targeted therapy monoclonal …
circulation. Forty years after its discovery, the new CGRP-targeted therapy monoclonal …
Calcitonin gene-related peptide (CGRP)-targeted therapies as preventive and acute treatments for migraine—the monoclonal antibodies and gepants
CC Chiang, TJ Schwedt - Progress in brain research, 2020 - Elsevier
Abstract Calcitonin Gene-Related Peptide (CGRP) plays a pivotal role in migraine
pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies …
pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies …
Calcitonin gene-related peptide-targeting drugs for migraine: how pharmacology might inform treatment decisions
L Al-Hassany, PJ Goadsby, AHJ Danser… - The Lancet …, 2022 - thelancet.com
Migraine is the second most disabling disorder across all age groups worldwide. Since
2018, two classes of drugs that inhibit the actions of calcitonin gene-related peptide (CGRP) …
2018, two classes of drugs that inhibit the actions of calcitonin gene-related peptide (CGRP) …
[HTML][HTML] Calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale
Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …
[HTML][HTML] Gepants for acute and preventive migraine treatment: a narrative review
JP Rissardo, ALF Caprara - Brain sciences, 2022 - mdpi.com
Calcitonin gene-related peptide (CGRP) antagonists are a class of medications that act as
antagonists of the CGRP receptor or ligand. They can be divided into monoclonal antibodies …
antagonists of the CGRP receptor or ligand. They can be divided into monoclonal antibodies …
Calcitonin gene‐related peptide modulators–The history and renaissance of a new migraine drug class
R Hargreaves, J Olesen - Headache: The Journal of Head and …, 2019 - Wiley Online Library
Several lines of evidence pointed to an important role for CGRP in migraine. These included
the anatomic colocalization of CGRP and its receptor in sensory fibers innervating pain …
the anatomic colocalization of CGRP and its receptor in sensory fibers innervating pain …
[HTML][HTML] New generation gepants: migraine acute and preventive medications
D Moreno-Ajona, MD Villar-Martínez… - Journal of clinical …, 2022 - mdpi.com
Migraine is a debilitating disease whose clinical and social impact is out of debate.
Tolerability issues, interactions, contraindications, and inefficacy of the available …
Tolerability issues, interactions, contraindications, and inefficacy of the available …
CGRP and migraine: the role of blocking calcitonin gene-related peptide ligand and receptor in the management of migraine
K Maasumi, RL Michael, AM Rapoport - Drugs, 2018 - Springer
Migraine is a highly prevalent, complex neurological disorder. The burden of disease and
the direct/indirect annual costs are enormous. Thus far, treatment options have been …
the direct/indirect annual costs are enormous. Thus far, treatment options have been …
Real world considerations for newly approved CGRP receptor antagonists in migraine care
Introduction Migraine is the leading cause of years lived with disability in people under 50.
Electrophysiological phenomena at the basis of prodromal and headache attack phases and …
Electrophysiological phenomena at the basis of prodromal and headache attack phases and …
CGRP-based migraine therapeutics: how might they work, why so safe, and what next?
AF Russo - ACS pharmacology & translational science, 2018 - ACS Publications
Migraine is a debilitating neurological condition that involves the neuropeptide calcitonin
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …