Kidney renal clear cell carcinoma (KIRC) is one of the most common cancers globally, with
an overall poor prognosis. The Janus kinase (JAK) family plays an essential role in cellular …

Background Phosphoinositide 3-kinases (PI3Ks) are lipid enzymes that regulate a wide
range of intracellular functions. In contrast to Class I and Class III PI3K, which have more …

Clear cell renal cell carcinoma (ccRCC) is known as the most aggressive subtype of
genitourinary cancers. The lack of effective therapies has prompted us to further explore the …

Abstract Background Spi-1 proto-oncogene (SPI1), which encodes an ETS-domain
transcription factor, can activate gene expression in myeloid and lymphoid lineages. The …

To investigate the molecular mechanisms underlying altered T cell response in renal cell
carcinoma (RCC) patients, we compared autologous and allogeneic CD8+ T cell responses …

Abstract Objectives Janus Kinase 3 (JAK3) mediates cytokine signaling and T-cell activation.
We hypothesized that JAK3 mutations may contribute to the development and progression of …

Specific kinds of interleukin (IL) receptors are known to mediate lymphocyte proliferation and
survival. However, recent reports have suggested that the high expression of IL4Rα and …

Background: Traditional clinicopathological features (TNM, pathology grade) are often
insufficient in predictive prognosis accuracy of clear cell renal cell carcinoma (ccRCC). The …

Janus kinases are a family of non-receptor tyrosine kinases involved in autoimmune
diseases and malignancies. In breast cancer, the immune related role of JAK2 remains …

Background Renal cell carcinoma (RCC) is a fatal disease, in which the PI3K/AKT/mTOR
signaling pathway serves an important role in the tumorigenesis. Previous studies have …