The brain is one of the most energy-consuming organs in the body. Satisfying such energy
demand requires compartmentalized, cell-specific metabolic processes, known to be …

Alzheimer's disease (AD) represents the most common form of dementia among older age
subjects, and despite decades of studies, the underlying mechanisms remain unresolved …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder that displays
pathological characteristics including senile plaques and neurofibrillary tangles. Metabolic …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …

Abstract Alzheimer's disease (AD), a well known aging-induced neurodegenerative disease
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …

Historically considered as accessory cells to neurons, there is an increasing interest in the
role of astrocytes in normal and pathological conditions. Astrocytes are involved in …

Neurological diseases can be broadly divided according to causal factors into circulatory
system disorders leading to ischemic stroke; degeneration of the nerve cells leading to …

There is a growing body of evidencethat indicates that the aging of the brain results from the
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …

As part of the blood-brain-barrier, astrocytes are ideally positioned between cerebral
vasculature and neuronal synapses to mediate nutrient uptake from the systemic circulation …

Alzheimer disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before …