Long‐term use of everolimus for refractory arrhythmia in a child with tuberous sclerosis complex

C Hofmann, S Syrbe, J Hebe, J Kreft… - American Journal of …, 2024 - Wiley Online Library
Tuberous sclerosis complex is associated with the occurrence of cardiac rhabdomyomas
that may result in life‐threatening arrhythmia unresponsive to standard antiarrhythmic …

Everolimus for severe arrhythmias in tuberous sclerosis complex related cardiac rhabdomyomas

MP Silva‐Sánchez… - American Journal of …, 2021 - Wiley Online Library
Intracardiac rhabdomyoma is the most common primary cardiac tumor in children. Most
cases are associated with tuberous sclerosis complex (TSC). Most of them are asymptomatic …

Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia

F Öztunç, SU Atik, AO Güneş - Cardiology in the Young, 2015 - cambridge.org
Rhabdomyoma is the most common cardiac tumour in children often associated with
tuberous sclerosis. Arrhythmia caused by cardiac rhabdomyomas may be the initial sign of …

Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma

S Ninic, M Kalaba, B Jovicic… - Annals of …, 2017 - Wiley Online Library
Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who
developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy …

Everolimus for the treatment of tuberous sclerosis complex–related cardiac rhabdomyomas in pediatric patients

N Dahdah - The Journal of pediatrics, 2017 - jpeds.com
Cardiac rhabdomyoma (cRHM), a benign, smooth-muscle hamartoma, occurs
predominantly in infants and children; approximately 75% of affected children are aged≤ 1 …

Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous …

EV Stelmaszewski, DB Parente, A Farina… - Cardiology in the …, 2020 - cambridge.org
Introduction: Tuberous sclerosis complex is a rare genetic disorder leading to the growth of
hamartomas in multiple organs, including cardiac rhabdomyomas. Children with …

[HTML][HTML] Successful treatment of arrhythmia-induced cardiomyopathy in an infant with tuberous sclerosis complex

N Motoki, Y Inaba, S Matsuzaki, Y Akazawa… - BMC pediatrics, 2016 - Springer
Background Tuberous sclerosis complex (TSC) is an autosomal-dominant tumor suppressor
gene syndrome that is characterized by the development of distinctive benign tumors and …

[HTML][HTML] Use of everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: benefits and complications

E Sagiv, SM Chikkabyrappa, J Conwell… - Annals of Pediatric …, 2022 - journals.lww.com
We report treating a term neonate with tuberous sclerosis and giant rhabdomyomas who
presented with incessant supraventricular tachycardia with Everolimus. The treatment was …

Rapid response of a cardiac rhabdomyoma causing severe right ventricular outflow obstruction to Sirolimus in an infant with negative genetics for Tuberous sclerosis

Y Nir-David, S Brosilow, A Khoury - Cardiology in the Young, 2021 - cambridge.org
Mammalian target of rapamycin inhibitors was found recently to be an effective treatment for
manifestations of Tuberous sclerosis complex, including cardiac rhabdomyomas. Most …

Cardiac rhabdomyomas in tuberous sclerosis complex

J Castro-Monsalve, JL Alvarado-Socarras… - The Journal of …, 2018 - jpeds.com
A male infant born at 31 weeks' of gestation and weighing 1700 grams presented with
sudden cardiac arrest at the birth hospital. The infant was transferred to the neonatal …