Background Mucus dehydration and impaired mucus clearance are common features of
cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). In CF, inhaled …

Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The
major cause of mortality and morbidity is lung disease with increasing pulmonary …

Background Impaired mucus clearance and airway mucus plugging have been shown to
occur in moderate–severe asthma, especially during acute exacerbations. In cystic fibrosis …

Inhalation of hypertonic saline (HS) acutely enhances mucociliary clearance (MC) in both
health and disease. In patients with cystic fibrosis (CF), repeated use of HS causes a …

Background Hypertonic saline is a hyperosmolar agent which increases mucociliary
clearance in CF but there is little data available on its effectiveness in bronchiectasis. Aim To …

Background Hypertonic saline (HS) is commonly prescribed for children with cystic fibrosis
(CF) despite the absence of strong data indicating clinical efficacy in a population with mild …

The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway
surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within …

Background Inhaled hypertonic saline (HS) has been shown to increase mucociliary
clearance (MCC) and improve clinical outcomes in adults and adolescents with cystic …

Bronchiectasis occurs as a result of a vicious circle consisting of an impaired mucociliary
transport system, inflammation, and infection and repair of the airways. Damage to the …

Background Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-
term trials, improves lung function in people with cystic fibrosis. We tested the safety and …